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OmnicSee also TamsulosinRoman nameOmnicThe composition and the form of1 capsule c modified release contains tamsulosine hydrochloride 0.4 mg; blistere in 10 pcs. , in box 1, or 3 blisters.PharmacokineticsQuickly and almost completely absorbed from the digestive tract, bioavailability is about 100%. After receiving a single 400 µ g C_max the six hours Equilibrium concentration (reception day) at 60-70% higher than C_max after a single injection. At 99% binds to plasma proteins. The volume of 0.2 l / mm Most of the blood in an unmodified form. T_1/2 10 h. Slowly metabolized in the liver with the formation of active metabolites. Report the news, with only 9% is in an unmodified form.Clinical pharmacologyImpact tone smooth muscles prostate cancer, uterine bladder prostaticescoy part of the urethra, improves urine flow, reduces symptoms of obstruction and irritation urinary tract in good hyperplasia of prostate cancer and some other diseases prostate gland and the lower Divisions urinary tract. There is not associated with альфа_1B-адренорецепто рами smooth muscle pressure without causing clinically meaningful reduction of AD in patients with arterial hypertension and in patients with initially normal AD.IndicationsSymptoms in good hyperplasia of prostate cancer and some other diseases prostate gland and the lower urinary tract.ContraindicationsHypersensitivity, ortostatical gipotenzia in disorder, severe liver failure.Side-EffectsRarely, dizziness, retrogradnaya God; Nausea, vomiting, diarrhea, constipation; In a few cases, headache, fatigue, rapid heartbeat, ortostatical gipotenzia; very rarely, allergic reactions (skin rash, itching, swelling angioneuroticeski).Patient interactionDo gipotenzivny effect альфа_1-адреноблокато��ов. Zimetidin increases and decreases furosemide concentration in plasma. Diclofenak warfarin and increase speed breeding.OverdosingThere has been cases of acute drug overdose. Theoretically, the overdose there is a possibility of a severe hypotension, which would require the appointment of additional cardiotropna therapy. If symptoms persist, should be objemozameshchate solutions or sossoudossoujiwate drugs. To prevent further drug intake may wash stomach reception activated charcoal or osmotic slabitelnogo.PrecautionsBe wary when using propensity to Orthostatic Hypotension expressed by human liver and Cl creatinine below 10 ml / min. When signs Orthostatic hypotension (dizziness, weakness) to the patient or bring clothing.Dosing and AdministrationThe inside is not liquid, the first meal of the day squeezed enough water to 0.4 mg / sut.Storage conditionsList B. The temperature 15-25 ° CShelf life4The registration013915/01-2002 |
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