Proroxan

Chemical name

1-(2,3-Дигидро-1,4-бенздио ксин-6-ил)-3-(3-фенил-1-пи��ролидинил)-1-пропанон (as hydrochloride)

Gross

C21-H23-N-O3

Characteristics

White or yellowish white crystalline powder. It is soluble in water and alcohol.

Of drugs

The drugs-gipotenzivne, sedative, antiabstinentnoe, protivozudnoe. Does postsinapticalkie alfa_1- and presinapticalkie альфа_2-адренорецепто��ы. And flaccid and the central influence. Ters of adrenergicakih sossoudossoujiwath counters eliminates patients and expands peripheral vessels, especially arteriola and prekapillara. Suppress diengjefalnah anxiety of the brain and regulates tone simpatoarenalova system.

Indications

Hypertonic kriz, diengjefalny kriz simpatoarenalovy type Ménière syndrome, sea and air sickness, cravings (morfinnaya and alcohol), тревожно-депрессивны�� syndrome, allergic Medicine.

Contraindications

Heavy forms of atherosclerosis, ischemic heart disease, a breach of cerebral circulation, circulatory insufficiency II stage breast age (up to 6 months).

Side-Effects

Aetiology and hypotension, increased stenocarditicakih pain.

Patient interaction

The growing neiroleptikami (fenotiazina derivatives, butirofenon, difenilbutilpiperidina, tioksantena). While novokainamida might decrease in the impactor heart.

Overdosing

Symptoms : aetiology, ortostaticeski collapse, a sharp decline Ad.lechenie : maintaining vital functions (mezaton, ephedrine, koronarolitiki etc.).

Precautions

The caution should be used in patients older. The contents of glucose in the blood (possibly increased endogenous insulin).

Dosing and Administration

Inside, in / m, c / GMT For heavily PNDS and diengjefalnah krizov : adult - 2-3 ml of 1% solution of n / a or / m children 1-2 ml of 1% solution in / m; for the prevention krizov : adult-on the inside 0,015-0,03 g 2-3 times per day, the children - 2 to 3 times a day dose pick depending on the age; with insomnia and zudath dermatozah-into 15-30 mg at night; prevention of motion sickness syndrome - 15-30 mg for 40 minutes before travel; morfinna in abstinence for 0.045 g three times a day for five days; alcohol-3 ml of 1% solution of n / a or / m 3 times a day. Higher doses for adults inside : single 0.06 g daily 0.18 g; Dropped : single 0.045 g daily 0.09 g.

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