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TonocardinSee also DoxazosinRoman nameTonocardinThe composition and the form of1 tablet contains doksazosine nelfinavir 2 or 4 mg; blistere in 10 pcs. , in box 2 blisters.PharmacokineticsWell drawn. C_max is about 2 hours Almost 98% is associated with plasma proteins. Bioavailability is about 65%. Return of the blood plasma in two phases T_1/2-22 p.m. Metabolised mainly by O-demetilirovania gidrauxilirovania and in the liver, 5% return with faeces in an unmodified form.FarmakodinamikaLower AD reaches through 2-6 h, the effect maintained for a period of 24 hours after admission. Does the level of blood lipids : increases the LPVP / total cholesterol, lowers levels of total triglycerides and cholesterol. Ingibiruet agregatia platelets, enhances the woven плазминоген-активато��а.Clinical pharmacologyAD increases and positive effects on lipid composition of plasma, can reduce the risk of ischemic heart disease. It features hyper left chamber.IndicationsArterial hypertension, clean giperpalazia prostate gland.Pregnancy and lactationPerhaps if the effect of therapy outweighs the potential risk to the fetus.ContraindicationsГиперчувствительност ь.Side-EffectsHeadache, dizziness, weakness, fatigue, swelling; Tachycardia (rarely, in its long-term use).Patient interactionCompatible with tiazidnami dioretikami, furosemidom, beta-adrenoblokatorami, blokatorami calcium channel ACE inhibitors, NPVS, antibiotics, oral противодиабетическим и preparations indirect antikoagulyantami, urikozuricescimi means.PrecautionsBe wary appoint patients with impaired liver, in combination with gepatotoksicskimi drugs. It should not be used in conjunction with the drivers of vehicles and people profession deal with high concentration (especially in the beginning of the course).Storage conditionsList B. The temperature 15-25 ° CShelf life4The registration014913/01-2003 |
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