Concor

Roman name

Concor #

The composition and the form of

1 tablet, film coated liner contains bisoprolola fumarata 5 or 10 mg; in a contour acheikova packing 10 pcs. , in a cardboard unit 3, 5 or 10 packages.

Of drugs

Gipotenzivne, antianginalnoe. Yes blocks beta_1-adrainoretseptora mainly heart. Virtually no effect on the smooth musculature of the bronchi and peripheral arteries, as well as glucose metabolism. Not having domestic simpatomimeticescoy activity.

Pharmacokinetics

Bioavailability of 90%. The liver becomes inactive metabolites. Excreted mainly kidneys, 50% in unaltered form.

Farmakodinamika

After one reception effect maintained for a period of one day. Decreases AD, and stroke, the frequency and duration of attacks increases tolerance to physical activity. In patients with chronic heart failure, as revealed in the Cardiac Insufficiency Bisoprolol Study II significantly (by 34%) reduces overall mortality.

Indications

Arterial hypertension, stenocardia, chronic heart failure (expressed moderate and severe; Stabilization of acute in the last six weeks).

Pregnancy and lactation

Valid only in exceptional cases (no admission, 72 hours before the expected delivery date).

Contraindications

Hypersensitivity, shock, AV blockade II and III extent syndrome weakness sinusnogo unit sinoatrialnaya blockade expressed aetiology (pulse less than 50 strokes / min), gipotenzia (Sad less than 90 mm Hg), the propensity to bronhospazmu, human peripheral blood (late stage).

Side-Effects

From the nervous system and sensory organs : a sense of fatigue, dizziness, headaches, sleep disturbance, depression (rarely); Reducing slezootdelenia, Kongunguit.so the circulatory system and blood (blood, gemostaz) : aetiology, the AV conduction, decompensation heart failure, increased symptoms in patients with peremejateisa hromotoy or syndrome Reynaud, rarely ortostatical Gipotenzia.prochie : muscle weakness, convulsions, the potency, reduced tolerance to glukoze (if it is accompanied by diabetes), skin itch.

Patient interaction

Together with the admission rezerpinom, metildofa, Clonidine, drugs naperstanki, guanfationom increased likelihood bradikardii; With calcium antagonists group verapamila and diltiazema-arterial hypotension, bradikardii, adults; With the derivatives ergotamine (eg protivomigrenoznami ergotaminsoderjasimi means) increased human peripheral blood circulation. Together with the use of insulin and oral saharoponijatmi means to strengthen gipoglikemii although its clinical features can be hidden (a control blood sugar).

Dosing and Administration

In hypertension, and ischemic heart disease : the inside, not liquid, squeezed small amounts of fluid every day-morning erh or at the luncheon on October 5 mg (liquid selected individually, in a cost-effective treatment and heart rate). In light forms hypertension (stage 1 classification WHO; Dad less than 105 mm Hg) sufficient dose in the treatment can be 2.5 Mg.pri chronic heart failure drug are beginning to be appointed to a 1.25 mg / day (1 week), and then increase the dose to 2.5 mg / day (1 week), 3.75 mg / day (1 week), 5 mg / day (4 weeks), 7.5 mg / day (4 weeks), and finally 10 mg / day (target dose). Konkora dose increased, depending on individual endurance under control and AD Pulsa.dla patients with liver or kidney mild no special selection doses.

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