Corvitol 100

Roman name

Corvitol # 100

The composition and the form of

1 tablet contains metoprolola tartrate 50, or 100 mg; blistere in 10 pcs. , in box 5 blisters.

Of drugs

Antianginalnoe, gipotenzivne, antiaritmicescoe. Yes blocks бета_1-адренорецептор��.

Pharmacokinetics

Absorbed more than 95%. Lipofilen, has been associated with the supply by 20%, is presistemnomu metabolizmu in the liver bioavailability of 50%. Evenly distributed in the body, easily penetrates the central nervous system. T_1/2, 3-4 p.m. Provided news in the form of inactive metabolites (excreted in the active form is not more than 3%). Renal failure does not result in meaningful change pharmacokinetics metoprolola, on the other hand, when zirrozah significantly increased bioavailability (up to 84%), T_1/2 increases (up to 12 hours) and decreases Cl.

Farmakodinamika

Has negative dromo-, chrono, and batmo- inotropnami effects reduces the need for hospitalization of oxygen, reduces the activity of plasma renin. Gipotenzivne due to a decrease in heart release and activity reninangiotenzinova system decreased sensitivity baroretseptorov, influence on the central nervous system; antianginalnoe-reduction requirements in myocardial oxygen transfer coronary blood flow in favour ishemizirovannah pockets, decreased sensitivity heart to the effects of the sympathetic innervation. antiaritmicescoe-removal aritmogennah sympathetic affects the vascular system of the heart, automatic braking and the speed of bringing the AV node increases refrakternogo period.

Indications

Arterial hypertension I and II of the (possible monotherapy), stenocardia voltage, acute myocardial infarction and postinfarknetary period (treatment), migraine (prevention), tahiaritmia, dilatazionnaya idiopathic cardiomyopathy.

Pregnancy and lactation

With great care designate during pregnancy and lactation (in small quantities enters breast milk).

Contraindications

Hypersensitivity, sinusnogo syndrome unit predisposition to bronhospazmam (bronchial asthma, bronchial giperreakcia) labilnaya form of diabetes.

Side-Effects

Weakness, dizziness, headache (early treatment), aetiology, gipotenzia, AV blockade cardiac insufficiency, drowsiness, and the disorder, depression (rarely).

Patient interaction

Joint application with nitroglitzerinom or calcium antagonists (such nifedipina) could lead to dramatic hypotonia; with alcohol to enhance mutual depressive effect on the central nervous system, with narkoznami means, the sum easing sokratimosti attack. Enhance the effect of insulin (may mask symptoms gipoglikemii) reduces - gipoglikemicakih oral drugs.

Precautions

The caution (in the lower elementary levels) Designate a sick human peripheral blood (illness Reynaud, obliterirute of peripheral vessels), in the midst of general anesthesia, diabetes, feohromotsytome expressed violations of the kidneys and liver. Patients using contact lenses, it is necessary to take into account the possible reduction of slezna liquid. The prolonged treatment should be implemented in a gradual manner, under the supervision of a physician.

Dosing and Administration

Inside, daily doses of 100-200 mg, take 1 or 2 times a day. The maximum daily dose is 400 mg. The inefficiency alone can be combined with other classes antigipertenziveh, antianginalnah complications or drugs.

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