Metipranolol

Chemical name

4-[2-Гидрокси-3-[(1-метилэ тил)амино]пропокси]-2,3, 6-триметилфенол-1- acetate (and as hydrochloride or tartrate)

Gross

C17-H27-N-O4

Characteristics

The white crystalline powder and odourless with a molecular mass of 309.40.

Of drugs

The drugs-antianginalnoe, gipotenzivne, antiaritmicescoe. Beta-adrainoretseptora block. Has negative hronotroponam and batmotroponam negative effect reduces airway, the hotel and cordial release. Activity begins in 1-2 h after administration, negative effect hronotropony continues 10 am The blockade бета-адренорецепторо�� in bronchitis and bronhiolah could lead to Bronchus resistance.

Indications

Arterial hypertension, stenocardia voltage condition after myocardial infarction, and supraventrikuliarnae jeludockove adults, including digitalisnye, gipertrofica cardiomyopathy, anxiety syndrome vegetative dystonia, giperkineticeski syndrome (also for gipertireoze, feohromotsytome), tremor in the face of the reception preparations lithium.

Restrictions on the use of

Acute myocardial infarction, pregnancy, breast-feeding (should abandon breastfeeding).

Contraindications

Aetiology, AV blockade II extent hypotension, refrakternaya cardiac insufficiency, bronchoobstructive syndrome, progressive arteriosclerosis, hypoglycaemia, metabolic acidosis.

Side-Effects

Diarrhoeal disorders, aetiology, AV blockade, hypotension, cardiac failure, human peripheral blood circulation, bronhospazm, muscle weakness, a change of view, keratokongunguit, iridotsyklit, parestesia, sleep disturbance, fatigue, depression, hallucinations, dizziness, headache, decreased body mass index, the delay fluid swelling lungs, skin allergic reactions.

Patient interaction

Do effect tubokurarina, simpatolitikov, insulin and sulfanilamidnykh protivodiabeticakih funds vazodilatatorov, ergotamine weakens - adrenalin, glycosides naperstanki, aspirin; increase activity phenytoin, furosemide, zimetidin and hydralazine, lower-NPVS. Incompatible with MAO inhibitors, galogensoderjasimi anaesthetics, aymalinom, hinidine, verapamilom, Clonidine, mazindolom.

Overdosing

Symptoms : expressed aetiology, and gipotenzia acute cardiac Nedostaternsti.lechenie : beta-adrainomimetiki, symptomatic therapy.

Precautions

In order to avoid the syndrome of the lower dose or withdrawal of treatment should be carried out gradually during the treatment precluded admission of alcohol.

Dosing and Administration

Inside the food in individual dose. Beginning with the 10 mg twice a day for hypertension and 3-4 times a day with pain or strain adults, then weekly intervals gradually increase the dose to 10 mg, controlled variation (in the rest-at least 45 to 50); strokes to the average daily intake is 80 mg, with hypertension - 40-80 mg in adults and giperkineticescom syndrome 10-40 mg, gipertroficescoy with cardiomyopathy, and 240 mg, with the vegetative dystonia, 10-30 mg, in the treatment tremora no more than 30 mg.

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