Oxprenolol

Chemical name

1-[(1-Метилэтил)амино]-3-[ 2-(2-пропенилокси)фенок си]-2-пропанол (and as hydrochloride)

Gross

C15-H23-N-O3

Of drugs

The drugs-gipotenzivne, antianginalnoe, antiaritmicescoe. Does beta_1- beta_2-adrainoretseptora and has internal and simpatomimeticescoy мембраностабилизирую щей activity. Impact sensitivity of tissues to kateholaminam and central impulsaciu sympathetic to the field, suppresses renin secretion. Decreases curves, speed spontaneous initiation sinusnogo and ectopiceski drivers rhythm, Sad and cordial release. Minor injures airway diseases, reduces oxygen demand (including the physical strength). The blockade бета-адренорецепторо�� continued for 12 C.bystro and adequately absorbed from the gastrointestinal (90%). Absorption by effects of a "through the liver, so the material is 24-60%. The distribution of 1.1 l / mm Linking blood plasma proteins is about 80%, T_1/2 1-2 hours Metabolized in the liver and excreted from jelchew (95%), a small portion (5%) presented with urine in an unmodified form. Easily permeates through gistogematicalkie barriers (including GEB, placental), accumulates in the tissues. The concentration in the blood of the foetus is 40%, milk 30% of the level in the blood of the mother.

Indications

Arterial hypertension, secondary prevention of strokes voltage ekstrasistolica incredible (najeludochkovaya and ventricular arrythmia) gipertrofica cardiomyopathy, mitral prolapse valve myocardial infarction (with clinically stable condition patient), wegetososudistaya distonia with gipertoniceski over, giperkineticeski cardialny syndrome with anaemia, tireotoxicose and feohromotsytome, tremor (essencialny), anxiety (symptomatic treatment).

Restrictions on the use of

Chronic obstructive lung diseases, stenocardia Prinzmetala, the propensity to bradikardii, AV blockade I extent of peripheral blood circulation, a disease Reynaud, dysfunction liver, kidneys.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, AV blockade II extent sinoaurikuliarnaya blockade syndrome weakness sinusnogo unit gipotenzia (Sad below 100 mm Hg) expressed aetiology (less than 50 u. / min), cardiogenny shock sistolical Heart failure is quite functional class (NYHA on), bronchial asthma, diabetes mellitus, ketoacidosis, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : headache, dizziness, weakness, fatigue, sleep disturbance, irritability, emotional lability, peripheral neiropatia, parestesia, depression, sputannosti consciousness Galloucination.so part of the intestine : dry mouth, unpleasant feeling in the stomach, nausea, vomiting, diarrhea or Zapor.so the respiratory system : dizziness, bronhospasticskie Reaktion.so the circulatory system and blood (blood, gemostaz) : a sense of heart, symptomatic aetiology, cardiac insufficiency, AV blockade gipotenzia, increased peremejateisa hromota, lakopenia, Trombozitopenia.so the musculoskeletal system : artralgia, Sudorogi.prochie : allergies syndrome the hyper or hypoglycaemia, lower libido, impotence.

Specific guidance

Changes indicators in laboratory studies.

Patient interaction

Calcium antagonists reinforce the blockade beta-adrainoretseptorov, NPVS-weakened. Increases vazopressornyi effect adrenaline, antiaritmicski - hinidina and usage (over possible aetiology, the decline AV conduction). Nekalisberegate dioretiki weaken antiaritmicski effect. Heart glycosides may potenzirovti bradiaritmiu and conductivity of the heart. Increases of lidocaine plasma. While prazozina increased risk of Orthostatic Hypotension, ethanol-ortostaticski collapse; rezerpina or clonidine (clofelina) - bradikardii and congestive heart failure. The intravenous narcosis increase inotroponoe negative, and gipotenzivne bronhospasticescoe effect. M-holinoblokatora remove parasimpaticescoe oksprenolola influence.

Overdosing

Symptoms : dizziness, aetiology, incredible, gipotenzia, difficulty in breathing, akrozianoz, convulsions, in the most severe cases - Kollaps.lechenie : wash stomach, and the appointment of absorbent, the introduction of atropine, beta-adrainomimetikov (izoprenalin), sedation (diazepam, lorazepam), and drastic (dobutamin, dopamine, epinephrine, norapinefrin) products; where necessary, enact glukagona etc. symptomatic funds.

Precautions

After a long reception should be lifted gradually, within 1-2 weeks (migration to other beta-adrenoblokator as possible). In patients with diabetes receiving treatment, increases the likelihood of development gipoglikemii. It may mask clinical manifestations of hyperthyroidism (tachycardia). In feohromotsytome appointment only, in conjunction with альфа-адреноблокатор��ми. Recommended that the use of alcohol at the time of treatment. Be wary designate drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside; With strokes voltage to 20 mg three times a day (up to 80 mg twice a day); maximum daily dose of 160 mg; with hypertension, 80-100 mg in two reception average daily intake in alone in patients with mild and moderate form of 260 mg 2-3 reception.

Literature

DV Preobrazhensky, A. Sidorenko, Romanov NE, Shatunov IM Clinical pharmacology major classes of drugs antigipertenziveh / / Consilium Medicum .- 2000 .- T. 2 .- N 3 .- C. 99-127.

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