Vazocardin

Roman name

Vasocardin #

The composition and the form of

1 tablet contains metoprolola tartrate 100 mg; blistere in 10 pcs. , in box 5 blisters.

Of drugs

Antihypertensive, antianginalnoe, antiaritmicescoe. Yes blocks бета_1-адренорецептор��.

Pharmacokinetics

The ingestion absorbed 95%. Bioavailability of 50%. Linking plasma protein-10%. The volume of 5.5 l / mm Penetrates into breast milk. T_1/2-3.5 hours Report the news (95%), mainly in the form of metabolites (only 10% in an unmodified form).

Farmakodinamika

Decreases oxygen demand miocardom, cutting phase refrakternosti reduces sistolicescoe (for hypertension) and diastolicescoe (in a few weeks of therapy) AD reduces the activity of renin Plazma.podavlet automaticity sinusnogo unit urejaet curves, slowing AV conductivity decreases airway and anxiety attacks, heart ejection.

Indications

Arterial hypertension, giperkineticeski cardialny syndrome, myocardial infarction, Ray, adults. Preventing strokes, migraines.

Contraindications

Гиперчувствительност ь. AV blockade cardiogenny shock, asthma heart failure, diseases of the peripheral vessels, sinusova aetiology, chronic obstructive lung diseases, labilny insulinzawisimy diabetes, the metabolic acidosis.

Side-Effects

Diarrhoeal phenomenon, headache, dizziness, weakness, insomnia, depression, cough, aetiology, gipotenzia, heart failure, Reynaud syndrome, visual impairments, allergic reactions.

Patient interaction

Do effect antigipertenziveh and gipoglikemicakih drugs. Antiarrhythmic to deepen hypotension and bradycardia, Tricyclic antidepressants, barbiturates, nitroglycerin, dioretiki, oral contraceptives only gipotenzivny effect. Rifampicin reduces, zimetidin increases concentration in the blood. Increases concentration of alcohol in the blood and prolong it.

Overdosing

Symptoms : arterial gipotenzia, acute cardiac insufficiency, cardiogenny shock aetiology, difficulty in breathing, bronhospazm, vomiting, loss of consciousness, Generalized Sudorogi.lechenie : symptomatic. In bradikardii and violations conductivity shown in / in a bolusnoe atropine in the dose of 0.5-2.0 mg; sokratimosti decline occurred in / in a glukagona primary dose of 1-10 mg, then 2-2.5 mg / h drip; sudorozhnom syndrome, a slow in / in a diazepam.

Precautions

It should be remembered that vazocardin adversely affects the ability to manage the vehicles and to perform work requiring high speed mental and physical reactions.

Dosing and Administration

Inside (after eating at the same time) 100 mg (up to 200 mg) a day in two Priema.pri myocardial infarct : supporting dose 200 mg / day (morning and evening). In gipertireoze : 150-200 mg / day for 3-4 Priema.maximalnaya daily dose of 400 mg.

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