Reserpine

Chemical name

Methyl ester (3бета,16бета,17альфа,18б��та,20альфа)-11,17-диметок си-18- [ (3,4,5-триметоксибензои��)окси]йохимбан-16-карб��новой acid

Gross

C33-H40-N2-O9

Characteristics

D. zmeina rauwolfia. White or white with a yellow-brown powder melkochristalliceski. Easily soluble in glacial acetic acid, a very little rat on the airwaves, alcohol and chloroform.

Of drugs

The drugs-gipotenzivne, neuroleptic. The persistent decline in AD. Simpatolitik : in presinapticakih okonchaniah postganglionarnah fibers simpaticski the autonomic nervous system stimulates the release of vezikul norarenalina while a breach of its transport that the rapidly depleting stocks mediator. Provides the same neuron in the brain, helping to reduce the content of dopamine, serotonin and other neiromediatorov and leading development neirolepticski Effecta.horosho absorbed in the digestive tract. The blood plasma proteins binds weakly. Treated biotransformation in the liver with the formation of active metabolites. T_1/2 initial phase is 4.5 hours, the terminal, at 48-168 During the four days of 60% return with faeces, mostly unaltered and 8% memory (less than 1% in an unmodified form). The effect is in a few days and reaches its peak in 3-6 weeks. The duration of 1-6 weeks.

Indications

Arterial hypertension.

Contraindications

Hypersensitivity disease, epilepsy, Parkinson's disease, depressive state, saying the disease stomach and duodenal ulcers, Ulcerative Colitis, respiratory distress, feohromotsytoma, jelchnokamennaya disease, glaucoma, pregnancy, breast-feeding (at the time of treatment should stop breastfeeding).

Side-Effects

Ekstrapiramidnye disorders, headache, dizziness, weakness, drowsiness, depressed, giporeflexia violation of concentration, diarrhoea phenomenon : nausea, vomiting, diarrhoea, pain in the abdomen, gastrointestinal bleeding, anorexia; Xerostomia, aetiology, adults, the pain in the chest, peripheral edema, cough, and frequent urination, reduced libido and potency, allergic reactions.

Patient interaction

Do effects of alcohol, means oppressive CNS, beta-adrenoblokatorov, antidepressants (MAO inhibitors), gipotenziveh preparations ucashchaet adverse reactions to the appointment of cardiac glycosides and hinidina. Reduces the противопаркинсоничес ких and simpatomimetikov.

Precautions

People constantly receiving rezerpin should avoid activities that require greater attention and reaction speed.

Dosing and Administration

Inside; Adult-to 0.1-0.25 mg once a day. Children on 5-20 µ g / kg or 150-600 g / m ^ 2 body surface once a day, or dividing by 2 equal parts. The highest daily intake for adults 10 mg.

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