Dipivefrine

Chemical name

({+})-2,2-Диметилпропанов ой acid 4 -[гидрокси-2-(метиламин о)этил]-1,2-фениленовый broadcast (and as hydrochloride)

Gross

C19-H29-N-O5

Characteristics

The white crystalline powder, readily soluble in water.

Of drugs

The drugs-protivoglaucomnoe. Does adrenoretseptora lowering the inner pressure. Is "prolekarstvom" easily gets into the front chamber eyes, which is fermentativomu hydrolysis with the formation of adrenaline. Ogly adrenaline, a adrenergicakih adrenergic receptors distributed ciliarnae bones and tissue trabekuljarnuu eye reduces products vnutriglazna liquid and increases its Ottok.posle local applications outflow vnutriglazna liquid gradually increases and reaches a peak in 2 hours In appointing two times daily average reduction vnutriglaznogo pressure of 20-24%. In some cases, the operational inefficiencies so protivoglaucomnykh funds.

Indications

Otkratougolnaya glaucoma (monotherapy or in combination with other drugs protivoglaucomnami with their inefficiency), the vnutriglaznogo pressure by infectious diseases eyes.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, narrow-angle glaucoma, pregnancy, breast-feeding.

Side-Effects

Headache and angry close-stinging sensation and sadnenia the eye, follikuliarny conjunctivitis, midriaz, obratimaya makulopatia (in patients with remote hrustalikom), education adenohromovykh deposits in the conjunctiva and cornea, allergic reactions; Rarely tachycardia, in rhythm, arterial hypertension.

Patient interaction

Do (mutually), the other protivoglaucomnykh funds, pilocarpina, carbaholina, azetazolamida.

Precautions

To apply caution in patients with afakiei because in 30% of cases is reversible makuliarny swelling requiring cessation of treatment.

Dosing and Administration

Instillatin. The primary therapy for glaucoma-1 drop in the eye (or both eyes) every 12 hours When the patient to be transferred to other protivoglaucomny drug not belonging to a group adrenomimetikov is assigned to the usual dose of the day before the previous preparation.

Directory → Wegetotropona funds → Adrenomimeticalkie funds → Adreno- and simpatomimetiki (alpha, beta) → Dipivefrine