Pseudoephedrine

Chemical name

[S-(R*,R*)]-альфа-[1-(Метила��ино)этил]бензолметан��л (as hydrochloride, rezinata or sulfate)

Gross

C10-H15-N-O

Characteristics

D. released from the shoots grow ephedra (Ephedra 1.7 Bge.) , Which together with ephedrine. The chemical structure is pseudoephedrine hydrochloride. Clear needle crystals or white crystalline powder with low specific aroma, easily soluble in water and ethanol, a moderate in chloroform. Molecular weight 201.7.

Of drugs

The drugs-adrenomimeticescoe, sossoudossouerveshchee, bronhodilatirtee, antikongestivne. Is Alpha and бета-адреностимулиру��щее Effects. The pharmacological properties similar to ephedrine, but less active and toxic. Increase bronchi stimulates the heart, narrow vessels and increases AD brings forth. Institute альфа-адренергически�� receptors receptacles mucous membrane lining the airways and lead to a narrowing. Decreases hyperemia tissue edema and zalojennosti nose improves patency of nasal. Has seasonal evolution of the nose and sinuses opening holes zakuporenna yevstahieva pipe. Shown effective in the treatment of enuresis at (when you cough or other efforts) and the weakness of renouretheral сфинктера.Исследован��я animal not identified tertogennogo action on the fetus, but pseudoephedrine lowering the average mass and the length of the body, the rate of bone in the skeleton of the fetus Zivotnykh.posle reception inside moves through 15-30 minutes, the maximum effect was achieved in 30 to 60 minutes, the duration of the four-hour Metabolised in the liver (in part). Report the news (unchanged to about 55% -75%). In response acidic urine out speed increases. Penetrates into breast milk.

Indications

Bronchial asthma (mild and severe); Obstruguy bronchitis; Swollen nasal mucous membrane, letting okolonosovykh and yevstahieva pipes in rinite (acute, vazomotornyi, allergic), sinusitis (acute, podostry) aerootite mid otite (acute serous), incl. with the swelling yevstahieva pipes acute yevstahiite, krupe, acute traheobronhite in. incl. as a support for the combined therapy analgezirutmi, antihistamines, protivokashlevami, otharcivatmi means and antibiotics.

Restrictions on the use of

Diabetes mellitus, predisposition to glaucome, Denmark prostate gland.

Pregnancy and lactation

Contraindicated in pregnancy (studies in humans should be held). At the time of treatment should stop breast-feeding (the risk of side effects simpatomimeticakih amines for newborn and premature babies).

Contraindications

Hypersensitivity, including other simpatomimetikam, arterial hypertension, koronaroateroskleros, arteriosclerosis cerebrovascular, cardiac insufficiency, Ray, insomnia, pregnancy, breast-feeding, child age (up to 12 years).

Side-Effects

From the nervous system and sensory organs : tremor, anxiety, mental institute, insomnia, less often, dizziness, headache; Rarely (in high doses), convulsions, hallucinations, oppression Zns.so the circulatory system and blood (blood, gemostaz : slowing or accelerating the pace of the heart, palpitation, irregular, коллапс.Аллергически�� reactions : skin Sapi.prochie : dizuria, anorexia, vomiting, sweating, difficulty breathing, weakness, paleness.

Specific guidance

There is a need to take the drug a few hours before sleep, to minimize the potential for insomnia.

Patient interaction

Funds for inhalation narcosis, incl. chloroform, alothane, trihloroetilen and other derivatives of hydrocarbons (increased sensitivity to attack pseudoephedrine), naperstanki drugs levodopa and increase the risk of developing heavy jeludockovh arrhythmias. Reduces effect antigipertenziveh and dioreticakih funds beta-adrenoblokatorov increases, drugs that stimulate the central nervous system. Soli citric acid increases the duration (less speed out with the urine). Cocaine (with the software on the mucous membranes) strengthens the cardiovascular system (each), and increases the risk of adverse effects. MAO inhibitors, including selegilin (due to the accumulation of catecholamines in vnutrineironalnah depot), furazolidon, procarbazine, simpatomimetiki, incl. agonists бета-адренорецепторо�� hormones and thyroid potenziruut efficiency and increase the possibility of side effects. Ters antianginalny effect nitrates. Alkaloids rauwolfii undermine (due to depletion of catecholamines).

Overdosing

Symptoms : convulsions, hallucinations, the AD change heart rhythm (slow-growing, the violation), incl. expressed and / or long expressed or prolonged cough, shortness or breath palpitations, unusual nervousness dwigatelnoe annoyance or Whobussion.lechenie : washing stomach, the appointment of vomit (no later than four hours after the overdose), activated charcoal (no later than 1 hour after the overdose) normal kidney function-bang diurez (with heavy overdose is not recommended). If there is evidence of toxicity on the heart-introduction propranolola (in / in), with gipokaliemii - dilute solution of potassium chloride (in / in cefuroxim), and deliria or convulsions, diazepam (in / in). There is a need for monitoring of the cardiovascular system, the definition of electrolytes in the blood serum.

Precautions

Be wary appoint older (information on the dependence of the effect of age in older people missing). Men older likely exaggerated prostate cancer, which may require dose adjustment. There should be appointed during the period of MAO inhibitors and within 14 days after the sanctions have been lifted.

Dosing and Administration

Inside, regardless of meals for 30-60 mg 2-3 times a day. The course of treatment is 10 to 20 days. Supportive therapy-30 mg / day (a few hours before the night of sleep).

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