Clonidine

Chemical name

2,6-Дихлор-N-2-имидазоли��инилиденбензамин (and as hydrochloride)

Gross

C9-H9-Cl2-N3

Characteristics

The white crystalline powder. Rat in the water, poorly soluble in alcohol, chloroform and ether.

Of drugs

The drugs-gipotenzivne, sedative. Prosecutor alfa_2-adrainoretseptora lowering tone sossoudodwigatelnogo the oblong brain and reduces impulsaciu in simpaticescom level peripheral nervous system presinapticescom level. It absorbed in the digestive tract. The maximum effect is 2-4 h is about 5 hours The duration of the range from 6 to 12 hours T_1/2-12 p.m. You can also quickly and easily penetrate through the GEB. Write mainly kidneys in an unmodified form. Lowers round, HR, heart ejection. Decreases products vnutriglazna fluid and improves its capital reduces inner pressure. Prolonged delay by water in the body. When a fast introduction to the short AD for the stimulation of peripheral adrenoretseptorov.

Indications

Hypertensive crises, arterial hypertension, myocardial infarction in the acute period (in the absence of a cardiogennogo shock and the concomitant increase AD), the primary otkratougolnaya glaucoma high - and middle-vnutriglaznogo pressure, the withdrawal syndrome opiates (composed of combination therapy).

Restrictions on the use of

Pregnancy, breast-feeding (should abandon breastfeeding), work related to the need for speedy mental or physical reaction.

Contraindications

Hypersensitivity, cardiogenny shock arterial gipotenzia, obliterirute of peripheral arteries, AV blockade II extent syndrome weakness sinusnogo unit depressive moods.

Side-Effects

Brown mouth, constipation, weakness, drowsiness.

Patient interaction

Gipotenzivny effect weakens nifedipin. In applying the neiroleptikami a mutual strengthening of sedation can be expressed depressive disorders.

Overdosing

There is a violation of consciousness, collapse, for the acute poisoning is aetiology, details of Micro may slow AV conduction syndrome early repolarization. Treatment of symptomatic.

Dosing and Administration

Inside, parenteral drops in the eye. Doses and treatment scheme unique.

Directory → Wegetotropona funds → Adrenomimeticalkie funds → Alfa-adrainomimetiki → Clonidine