Dopegit

Roman name

Dopegyt

Pharmacokinetics

Absorbed about 50%. Up to 10% of dose is metabolized education alfa-metildofamina and then альфа-метилнорадрена��ина. Linking plasma protein up to 20%. The distribution is not more than 0.29 l / kg Penetrates the GEB. Kidney Cl-about 130 ml / min, T_1/2 no more than eight hours (with kidney failure increased). Complete off occurs, on average, within 36 hours Write mainly via the urine (70%), unedited, as well as a sulfokongugatov. With long-term use koumouliruet.

Farmakodinamika

Decreases round and AD. Sale of blood has not changed. Increases speed clubockova filtering and kidney blood, lowers renin levels in plasma. Delays excretion of sodium and water. Provides moderate sedative effect. Once inside antigipertenzivny maximum effect occurs four to six hours and lasts 1-2 days.

Indications

Arterial hypertension mild and severe, incl. Hypertension among pregnant.

Pregnancy and lactation

The drug of choice in the treatment of hypertension in pregnant women. The application through breastfeeding (if the effect of therapy outweighs the potential risk to the child, because the drug enters the breast milk).

Contraindications

Hypersensitivity, hepatitis, liver and kidney failure, feohromotsytoma, depression, Autoimmune Hemolytic Anemia, porphyria.

Specific guidance

During the period of treatment of patients treated with a standing dark color (with the reaction product and its metabolites).

Patient interaction

It should not be used in combination with MAO inhibitors as a result of increased unwanted effects : possible as increased arterial hypotension, and the concerns of hypertension (kriz) with a motor возбуждением.Совмест��ое Appointment with tricyclic antidepressants fail because may decline antigipertenzivnogo action and the emergence of tachycardia, mental stimulation and head Boli.pri combination of levodopa with Dopegitom ® may increase антипаркинсоническог о effect from braking decarboxylation levodopa on the periphery as a result of Dopegita ®, which is leading to more levodopa concentration in the CNS. However, if braking decarboxylation prevails in the central nervous system, antiparkinsoniceski effect of levodopa reduced. Furthermore, there is an additive effect gipotenzivny and in the sharing of Dopegita ® nacomom (levodopa + carbidopa) can ortostatical gipotenzia. In this case, after taking the drug to patients in a horizontal position for a period of 1-2 C.dla strengthen antigipertenzivnogo effect simultaneous appointment Dopegita ® apressinom, dioretikami and nifedipinom is rational. The joint application Dopegita ® verapamilom, captoprilom or prazosinem. Dopegit not apply with Clonidine or резерпином.Совместно�� use Dopegita ® �ета-адреноблокаторам и wrong : observed Orthostatic Hypotension, in some cases it is likely to gipertoniceski kriza, which is formed from metildopa �льфа-метилнорадренал ин.Назначение indometacin and other NPVS may reduce the effect antigipertenzivnogo Dopegita ® through inhibition NG with vazodilatiruta �ктивностью.Комбинаци я Dopegita ® tranquilizers rational : there may be a greater antigipertenzivnogo Actia.pri raising pH urine, at the reception the patient alkaliziruth urine PP, the Dopegita ® growing : product concentration in the blood is kept at a high level for longer periods of time, as a result of an increase in reabsorbtion kidney Kanalzah.v a simultaneous reception Dopegita ® and atsidifitsiruth urine PP antihypertensive action of the preparation declining since the ionization metildopa as weak grounds while lowering the pH in urine increased, which means that there is a decrease in reabsorbtion kidney and bone accelerated withdrawal Pockami.u patients receiving Dopegit ®, at the time of narcosis may kollaptoidnyi development of the state, so no admission for the 10 days before the narcosis; when it is not possible to the drug with caution apply ftorotan or tiopental-natri. Ethylene glycol for narcosis contraindications.

Precautions

Patients with impaired kidneys, it is necessary to reduce the daily dose. For elderly patients (including the elderly) age when it is necessary to gradually increase the daily dose (due to the sharp downward AD). It should be borne in mind that, after the cessation of the use of antihypertensive activity relatively quickly terminated, the AD is usually within 48 hours. The therapy required monitoring liver function and the picture peripheral blood. With long-term therapy in the first 10 weeks of treatment and every 6 to 12 months is recommended that the sample Kumbsa; If you have a direct positive test Kumbsa and hemolytic anemia requires removal treatment and the appointment of glucocorticoids. In the event of a delay fluid in the body and the emergence of trauma appoint dioretiki, with the dose of the drug reduced. In combination with other antigipertenzivei means to reduce the daily dose. At the time of treatment precluded admission of alcohol. At the start, individually specified period of Dopegita ®, is not allowed to drive vehicles and some other potentially dangerous activities that require rapid mental and motor reaction. The further treatment of restrictions set depending on the individual endurance preparation.

Dosing and Administration

Inside, dose picked individually, adults usually in the first two days, 250 mg / day (evening, at night), then the daily dose gradually increased (every 2 days at 250 mg) to 1-1,5-2 grams (maximum) in the reception 2-3 depending on the extent of reducing AD. In achieving lasting effect gipotenzivnogo daily dose gradually reduce (every 2 days at 250 mg) to maintain the minimum effective dose.

Storage conditions

List B. The temperature 15-25 ° C

Shelf life

5 years

The registration

012744/01-2001

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