Guanfacine

Chemical name

N-(Аминоиминометил)-2,6-��ихлорбензолацетамид (in the form of monogidrohlorida)

Gross

C9-H9-Cl2-N30

Of drugs

The drugs-gipotenzivne. It stimulates the central альфа_2-адренорецепто��ы presinapticakih membranes sossoudodwigatelnogo point down for the norarenalina reduces impulsaciu on simpaticakim fibres autonomic nervous system. And альфа_1-адреномиметич��ским influence on the peripheral adrenoretseptora and is (can be) hypertension. Overall, the short-term moderate vazokonstrikciei a sufficiently long vazodilatation. Gipotenzia accompanied by a decline in heart emission bradikardiei lower round. Improves outflow watery moisture, it reduces the secretion, inner pressure. And laboratory and analgezirutmi properties. Somato-wegetativee stops of the drug and alcohol abstinence. Quickly and completely absorbed in the intestine, are poorly connected with blood plasma proteins. C_max plasma observed after 3 h after administration, T_1/2 about 2:00 pm Provided urine in an unmodified form.

Indications

Hypertonic kriz, hypertension, primary otkratougolnaya glaucoma.

Restrictions on the use of

Violation conductivity, vnutriserdechne blockade expressed depression, cerebrovascular disease.

Contraindications

Cardiogenny shock, hypertension different origins.

Side-Effects

Brown mouth, constipation, sedation, drowsiness, a feeling of tiredness, weakness, upgradeable AD (in the first admission).

Patient interaction

Gipotenzivny effect weakened drugs. Sedating properties reinforce high doses doses.

Overdosing

Symptoms : human consciousness, Kollaps.lechenie : symptomatic.

Dosing and Administration

Inside. Adults appoint 1 mg at night (the trigger sedatia and long gipotenzivny effect). If necessary, the daily dose increased to 23 mg. Increase and reduce the dose should be gradual, not more than 1 mg (or 50% of the baseline) in the week.

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