Midodrine

Chemical name

2-Амино-N-[2-(2,5-диметокс��фенил)-2-гидроксиэтил] ацетамид (and as hydrochloride)

Gross

C12-H18-N2-O4

Characteristics

Crystalline powder white odourless. It is soluble in water and low in methanol.

Of drugs

The drugs-sossoudossouerveshchee, gipertenzivne. Forms active metabolite, which is an agonist альфа_1-адренорецепто��ов and interact with them and arteriolah venulah. Increases tone receptacles and AD. Has no incentive effects for the альфа-адренорецептор�� Heart, HR, airway attack does not affect the smooth muscle layer bronchi. It permeates through the GEB and no effect on the central nervous system. When used in the dose of 10 mg in patients with Orthostatic gipotenziei increases AD 15-30 mm Hg after one hour after the introduction; effect may persist for 2-3 C.posle intake of rapidly absorbed. Absolute bioavailability 93% is not dependent on the meals. The blood only partially associated with the protein. C_max plasma achieved in 1-2 hours, T_1/2 is 3-4 hours The way biotransformation - deglitination. Desglimidodrin (major metabolite) formed in many tissues. The final degradation occurs in the liver. Return with urine (by renal glands) almost completely within 24 h : in the form of active metabolita (40%), unchanged drugs (5%) and inactive metabolites (55%).

Indications

Ortostatical gipotenzia Arterial gipotenzia (including the criteria for psychotropic drugs during convalescence after the operation and delivery) gipotenzivee response to the changes of weather, accidental pollution as a result of a breach of the pouches bladder.

Contraindications

Zakratougolnaya glaucoma, arterial hypertension, feohromotsytoma, obliterirute spasticskie and Vascular Diseases, thyrotoxicosis and severe kidney failure, prostate adenoma cancer delayed shock, mechanical obstruction of the urinary tract, pregnancy.

Side-Effects

The AD in the trunk, reddening of aetiology, violations of urination (frequency or delay), headache, dizziness, insomnia, drowsiness, fatigue, paresthesia, a sense zabkosti, itchy skin, stomach, dry mouth, nausea, diarrhoea phenomenon, flatulence, decrease muscle that raises hair ( "goose" skin), skin rash.

Patient interaction

Heart glycosides potenziruut bradycardia risk AV blockade and adults. Adrenomimetiki (pseudoephedrine, ephedrine, phenylpropanolamine) reinforce adrenoblokatora (prazosin, doksazosin) - weakening effect.

Overdosing

Symptoms : hypertension, aetiology, zabkosti sense, "flying" skin whose Mocheispuskania.lechenie : provocation vomiting, stomach scene, the introduction of альфа-адреноблокатор��в (fentolamin).

Precautions

The caution used in heart failure, arrhythmia, human liver and kidneys (usually require dose adjustment and the introduction). In combination therapy with drugs and drug dependence are treated with 2.5 mg, gradually increasing to 5 mg 2-3 times a day. High kidney Cl metabolita core product (due to the active tubularna Pepsi) to be taken into account in the sharing of the metforminom, ranitidine, prokainamidom, triamterenom, guanidine.

Dosing and Administration

Inside, in / m, / 386/1989 Inside-2.5 mg twice a day by injection, 5 mg twice a day, if necessary dose gradually increased at intervals of one week (no more than 30 mg per day). After clinical effect dose reduced to 1.25 mg once a day. The child shall practice with the body mass index.

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