Bertek

Roman name

Berotec

Pharmacokinetics

Depending on the method of inhalation, and the inhalation of about 10-30% of the active substance released from the aerosol product after inhalation, reaches the lower respiratory tract and the rest deposited in the upper respiratory passages and proglatavetsa. As a result, a number of ingaliruemogo fenoterola enters the digestive tract. After inhalation one dosage level of intake is 17% of the dose imposed. Suction is a two-phase nature of 30% fenoterola hydrobromide is rapidly absorbed with T_1/2 11 min, and 70% absorbed slowly with T_1/2 120 Min.posle inside the skin about 60% fenoterola hydrobromide. Time to C_max blood plasma-2h Linking plasma protein-40-55%. Metabolised in the liver. Report the news and jelchew as inactive sulphate Kongugatov.pri Injecting a fenoterola gidrobromid displayed the phase model T_1/2 - 0.42 min, 14.3 minutes and 3.2 hours Biotransformation fenoterola hydrobromide in humans has exclusively by conjugation with sulphates mostly wall Kishechnika.fenoterola gidrobromid can enter unaltered through the placental barrier and enter the breast milk.

Farmakodinamika

Fenoterol cautions and quickly eliminates bronhospazm different genesis. Early action after inhalation, in five minutes, maximum 90 minutes, the duration of 3-6 h.

Indications

Prevention and mild bronchospasm in bronchial asthma, chronic obstruguom bronchitis, emphysema lungs. Preventing asthma physical effort. Symptoms treatment of asthma and chronic obstructive lung disease.

Pregnancy and lactation

Contraindicated in the first trimester of pregnancy, a drug may II in a trimester of pregnancy and during breast-feeding only if the expected benefits of therapy outweighs the potential risk to the fetus or child.

Contraindications

Hypersensitivity, gipertrofica obstructive cardiomyopathy, tahiaritmii, heart disease, aortalny stenoses, decompensirovanny diabetes, thyrotoxicosis, glaucoma threatening abortion, pregnancy (I term).

Specific guidance

The first application of a new form of measured aerosol Bertek H ® patients may note that the taste new product differs slightly from the same pharmaceutical form containing freon. The transition from one form to another, patients must be warned of a possible change in the taste sensations. It is also reported that these drugs interchangeably, and that the taste not related to the safety and efficacy of new Preparata.drugie simpatomimeticalkie bronhodilatatora should be appointed at the same time as Berotecom ® H only under medical supervision.

Patient interaction

Beta-adrainergicakie and antiholinergicakie means xantinove derivatives (theofillin) can enhance bronhorasshiratee effect. The simultaneous appointment of other beta-adrainomimetikov entering the systemic blood antiholinergicakih or xantinovykh derivative (eg theofillina) can be increased by Effectov.vozmozhno significant weakening of bronhorasshiratego while appointment бета-адреноблокаторо��.Одновременное with the use of MAO inhibitors and tricyclic antidepressants aggravating Berteka ® Inhalation N. halogenated hydrocarbon anesthetics (alothane trichloroethylene, anfluran) may exacerbate the effects Berteka ® H cardiovascular Sistemu.na backdrop of Berteka ® H may gipokaliemii development, which could increase, while a xantinovykh derivatives, steroids and dioretikov. This fact should be given special attention in the treatment of patients with severe obstructive respiratory diseases Putei.gipokaliemia can lead to increased risk of arrhythmias in patients receiving digoxin. Furthermore, hypoxia may exacerbate the negative impact on gipokaliemii heart rhythm. In such cases, encouraged to monitor potassium levels in the serum.

Precautions

Be wary appoint diabetes recently relocated myocardial infarct, heavy Cardiovascular diseases, gipertireoze, Feohromotsytome.pri use beta_2-agonistov may develop serious Gipokaliemii.pri witty, fast-growing despnoe (breathing difficulty) should immediately consult with Vrachom.sleduet bear in mind that the use of short-attack high doses for long periods can cause uncontrolled deteriorating course of the disease and require correction standard �ротивовоспалительно�� Therapy inhalants �ортикостероидами.Осо бую caution should be used in severe bronchial asthma, as this effect can be enhanced by concomitant use of derivatives xantina, glucocorticoids and dioretikov. Furthermore, hypoxia may exacerbate the effects gipokaliemii the heart rhythm. In such situations the regular monitoring of potassium level in the serum.

Storage conditions

List B. In a temperature not exceeding 30 ° C (not freezing)

Shelf life

5 years

The registration

015273/01

Directory → Wegetotropona funds → Adrenomimeticalkie funds → Beta-adrainomimetiki → Bertek