Isoprenaline

Chemical name

4-[1-Гидрокси-2[(1-метилэ��ил)амино]этил]-1,2-бенз��лдиол (as hydrochloride, sulfate or tartrate)

Gross

C11-H17-N-O3

Characteristics

The white crystalline powder. Easily soluble in water. Aqueous solutions are greenish hue.

Of drugs

The drugs-bronhodilatirtee. Does beta_1- and бета_2-адренорецептор��. Activates adenilatziklazu, resulting in the accumulation of cells Zamf affecting the system proteinkinaza preventing miosin ability to connect to aktinom that prevents reduction smooth muscles and promotes relaxation Bronhov.obladaet expressed bronholiticakimi properties is increasing and strengthening of heartbeats, heart increases emissions. Impact round, diastolicescoe AD reduces ventricular filling heart, kidney bloodstream. Increases need heart of oxygen. Increase pressure abdominal, skin, mucous membranes, inhibits cancer reduction. Does the tucnami cells chemical factors (gistamina, slowly responsive substance-SRS-A or lakotrien D_4, etc.) to bronhospazmu phenomena and inflammation. T_1/2-2 p.m.

Indications

Cardiogenny shock (used relatively rarely-only when normovolemicescoy form to a higher round and the low emission heart), deep bronchial asthma (mild and prevention), chronic bronchitis with bronhoobstruktive syndrome, pnevmoskleros, aetiology (with inefficiency atropine), paroxizmalnaya bidirectional veretenoobraznaya ventricular tachycardia (with the difficult course).

Contraindications

Acute myocardial infarction. Angina, thyrotoxicosis, pregnancy (I trimester and before childbirth).

Side-Effects

Tachycardia, adults, nausea, tremor hands, dry mouth.

Patient interaction

Partly reduces antiaritmicski effect usage and reduces it with the period refrakternosti additional ways to engage in patients with Wpw-sindromom.

Overdosing

There palpitations, activated ectopiceskih pockets triggering ventricular ekstrasistoliei, fibrillaciei testing.

Dosing and Administration

As a means bronhorasshiratego subilgvalno-in the form of tablets (2.5-5 mg), 0.5% or 1% solution for inhalations of pocket, etc. ingalatora (dose of 0.1-0.2 ml) 3-4 times a day. When she cardiogennom in / drip in a 5% glucose solution at the speed of 0.5-5 g / min.

Directory → Wegetotropona funds → Adrenomimeticalkie funds → Beta-adrainomimetiki → Isoprenaline