Orciprenaline

Chemical name

5-[1-Гидрокси-2-[(1-метилэ тил)амино]этил]-1,3-бенз олдиол (as sulfate or rezinata); razemical mixture of the two optically active isomers

Gross

C11-H17-N-O3

Characteristics

The white crystalline powder.

Of drugs

The drugs-bronhodilatirtee, protiwastmaticescoe (warning bronhospazm) tokoliticescoe. Interfaces with бета_2-адренорецептор��ми smooth muscles bronchi, adenilatziklazu activates, creating Zamf number, which leads to a decrease in intracellular calcium and bronhodilatace. Ingibiruet release of biologically active substances from fat cells, improves mukotiliarnyi klirens; Cause tachycardia and increases the need heart of oxygen improves AV conductivity increases peripheral vessels and reduces AD. And tokoliticakimi properties (activates бета_2-адренорецептор�� in the smooth muscle of uterus). Depending on the path drawn from 3% (ingalaii) to 10% (enteralny). Metabolised in the liver. Return with faeces.

Indications

Bronchial asthma, obstruguy bronchitis, emphysema lungs, pnevmoskleros, bradiaritmii, AV blockade, the threat of premature births.

Contraindications

Hypersensitivity, asthma status, disease, tahiaritmii, heart disease, thyrotoxicosis and glaucoma.

Side-Effects

Tachycardia, hand tremor, muscle weakness, the decline AD, headache, dizziness, sweating, nausea, vomiting, addiction, tahiphylaccia.

Patient interaction

Do antidepressants effect; In the sharing of the бета-адреноблокатора��и possible phenomenon of idiosyncrasy.

Dosing and Administration

In / in the 0.5-1 mg (1 ml 0.05% solution) slowly for 3 minutes, or into 10-20 mg 3-4 times a day (the effect is a one hour and lasts 4-6 h), or ingalciah 0,75-1,5 mg (breaths 1-2), 3-4 times a day (effect occurs within 15 minutes, reaches its maximum after one hour and lasts 4-5 h).

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