Salmeterol

Chemical name

({+})4-Гидрокси-альфа-[[[6- (4-фенилбутокси)гексил ]амино]метил]-1,3-бензол диметанол

Gross

C25-H37-N-O4

Characteristics

White or no white powder, easily soluble in methanol, slightly soluble in ethanol, chloroform and isopropanol, sparingly soluble in water.

Of drugs

The drugs-protiwastmaticescoe, bronhodilatirtee. Selectively institute бета_2-адренорецептор��. Does intracellular adenilatziklazu increases Zamf education. The relaxation of smooth muscles bronchi and ingibiruet mediators release of fat cells. Has long (up to 12 h) The bronchi in patients with reversible bronchial obstruction. Regular admission salmeterola provides permanent improvements in the functioning of the lungs, reducing the severity syndrome obstructive airways and night attacks of asthma. Prevents release gistamina, lakotrienov and PGUD_2 of fat cells, the противовоспалительно й activity reduces the intensity of the primary and secondary responses to the bronchi 73.21 allergens.

Indications

Obratimaya obstruction of the respiratory tract : bronchial asthma (prevention of bronchospasm, which caused physical load or night asthma attacks), chronic bronchitis.

Contraindications

Hypersensitivity, pregnancy, breast-feeding (at the time of treatment to stop), a children's age (up to 12 years).

Side-Effects

Paradoxically bronhospazm (requires a reception), tachycardia, headache, tremor, nervousness, diarrhea, pain in the abdomen, nausea, viral gastroenteritis, gipokaliemia; Local reactions : rhinitis, laringit, irritation, skin itch.

Specific guidance

The shake well before use.

Patient interaction

MAO inhibitors and imipramine potenziruut depressant effect on the cardiovascular system. Derivative xantina, glukokortikoida dioretiki and increase the risk of gipokaliemii, especially in patients with severe asthma, as well as during hypoxia (mandatory control level in the blood plasma). Compatible (possible simultaneous inhalation of korticosteroidami and / or cromolinom sodium.

Overdosing

Symptoms : tachycardia and / or irregular, headache, tremor, and gipokaliemia Giperglikemia.lechenie : switch to alternative products, the introduction cardioselektiveh бета-адреноблокаторо��.

Precautions

Not applicable to heavily bronchoconstriction. The caution shall mean patients with thyrotoxicosis, patients with severe asthma with a hypoxia генеза.Терапевтическ��й effect can be reduced by cooling Ingalatora.esli recommended dose fail, it is necessary to increase them. It should be borne in mind that with the regular use of salmeterola most patients usually reduce the need for additional korotkoactuth симпатомиметиков.Нел��зя not getting spray in the eye.

Dosing and Administration

Inhalation. To prevent attacks of asthma, including night, the usual dose for adults and children over 12 years of age-2 inhalation (50 micrograms) twice a day (morning and evening). To prevent bronchospasm, which caused physical load-2 inhalation at least 30 to 60 minutes before exercise. When treating severe forms of asthma-100 µ g twice a day.

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