Terbutaline

Chemical name

5-[2-[(1,1-Диметилэтил)ами но]-1-гидроксиэтил]-1,3-б ензолдиол (in the form of sulfate)

Gross

C12-H19-N-O3

Characteristics

Crystalline powder from white to colour sero-belogo odourless or weak smell of acetic acid. Rat in the water, and 0.1 g. hydrochloric acid, poorly soluble in methanol, nerastvorim in chloroform.

Of drugs

The drugs-bronhodilatirtee, tokoliticescoe, противоаллергическое . Selectively institute beta_2-adrainoretseptora increases adenilatziklazy activity, stabilizes Zamf reduces the concentration of intracellular calcium and relaxes smooth muscles. Relaksiruet longitudinal muscle bronchus (bronchodilatory effect), reduced viscosity Bronchus secret, increases mobility cilia mertzatelnogo membrane (improves mukotiliarnyi Cl). 4-3 membranes fat cells (противоаллергически�� effect), inhibits release of mediators allergies (serotonin, gistamina etc.). Relaxes smooth muscles uterus (tokoliticescoe effect). After inhalation slowly absorbed from respiratory tract (most proglatavetsa and absorbed from the digestive tract). When s / to the introduction C_max achieved through 15-30 minutes. It permeates through the GEB, but passes through the placental barrier. Treated intensive biotransformation in the liver with the formation of active metabolites. Excreted kidneys, intestinal lactoirutmi dairy disorders. T_1/2 is 4 C.actie begins in 30 minutes after s / to the introduction, clinically meaningful improvement in the respiratory system is a 120 mines, reaches over 180 minutes and lasts for up to 4 hours

Indications

Bronchial asthma, asthma status obstruguy bronchitis, emphysema light, the acute cardiac insufficiency, fibrosny anesthetic, dismenorea first, the threat of premature births, fetal distress.

Contraindications

Hypersensitivity, pregnancy (as bronhodilatirutego means), breast-feeding (at the end of treatment), children's age (up to 12 years).

Side-Effects

Anxiety, insomnia, headache, dizziness, tremor, sweating, giperreflexia, weakness, midriaz, tachycardia, in rhythm, heart hyper or hypotension, nausea, heartburn, vomiting, bad taste in his mouth, atony bladder or allergic reactions.

Patient interaction

Increases activity adrenomimetikov other, the likelihood of side effects of antidepressants (tricyclic and MAO inhibitors). Adrenoblokatora, especially beta-adrainolitiki reduce the effect.

Overdosing

Symptoms : tremor, nervousness, the violation of consciousness, convulsions, headache, sweating, tachycardia, incredible, arrythmia and hypotension, nausea, vomiting, giperglikemia, smenauschayasa Gipoglikemiei.lechenie : washing stomach, the appointment of activated carbon, the maintenance of vital functions.

Precautions

In developing bronhospasticescoy paradoxical reaction, in response to a cloud terbutalin overturned.

Dosing and Administration

Inside (pills) in the adult dose of 5 mg every 6 h (in the case of taking the side effects of 2.5 mg three times daily); Children over 12 years of age is 2.5 mg three times a day. The maximum daily dose is : Adult-15 mg, and for children - 7.5 Mg.p / to the lateral deltoid area in the dose of 0.25 mg; In the absence of the effect for 15-30 minutes a re-injection in the same dose (following the introduction of no earlier than 6700). inhalation investigated (at intervals of 60 s), every 4-6 hours

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