Biperiden

Chemical name

альфа-Бицикло[2.2.1]гепт -5-ен-2-ил-альфа-фенил-1-��иперидинпропанол (as hydrochloride or lactate)

Gross

C21-H29-N-O

Characteristics

The white crystalline powder, odourless, poorly soluble in water and alcohol.

Of drugs

The drugs - противопаркинсоничес кое. Does n-holinoretseptora central and peripheral m-holinergicescuu transfer case; Recently the miotropona and spazmoliticaskie Effecta.c_max (1,01-6,53 ng / ml) is the greatest hour equilibrium concentration when administered 2 mg twice per day through 15,7-40,7 hours Associated with the plasma protein to 91-94%. Cl plasma at 11.6 ml / min / kg Fully metabolised. Major metabolites - biziklogeptan and pyridine. Eliminations implemented in two phases with T_1/2 1,5 h in the first phase and 24 h, in the second. Excreted kidneys and digestive tract. Bioavailability in giving blood is 33%. Penetrates into breast Moloko.umenishaet muscle rigidity, tremor and lunch violations, to a lesser extent, the symptoms of akinesia.

Indications

Parkinson's syndrome, ekstrapiramidnye disorders, psoriasis, akinesia in the treatment neiroleptikami and other drugs.

Contraindications

Zakratougolnaya glaucoma, megakolon, rhesus blood, tahiaritmii, Denmark prostate cancer, pregnancy, breast-feeding (at the time of treatment must be abandoned).

Side-Effects

Violation ccomodation, dry mouth, diarrhoea disorders, tachycardia, demotion AD fatigue, dizziness, drowsiness, sputannosti consciousness, impaired memory, hallucinations, drug dependency.

Patient interaction

Do effects holinolitikov, antigistaminnah, противопаркинсоничес ких and protivosudorozhnykh funds weakens - metoklopramida. Incompatible with alcohol. Quinidine increases holinoliticescoe influence levodopa, the risk of developing psoriasis.

Overdosing

Symptoms : expressed holinoliticaskie Effecta.lechenie : symptomatic. Perhaps the cholinesterase inhibitors.

Precautions

Be wary appoint the farm cerebrovascular (old age), epilepsy patients (to take into account the possibility of convulsant syndrome). Cease to treatment (high likelihood of the emergence of symptoms). Patients receiving the drug should refrain from activities potentially hazardous activities that require mental agility and propulsion reactions.

Dosing and Administration

Inside, in / in or / m. Dosage and frequency matched admission individually and depend on the evidence and the age of the patient.

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