Diphenyltropine

Chemical name

Тропиновый broadcast дифенилуксусной acid (as hydrochloride)

Gross

C22-H25-N-O2

Characteristics

White or white with weak кремоватым white crystalline powder. Easily soluble in water and alcohol.

Of drugs

The drugs-противопаркинсоническое, skin. Force on the result of the blockade is м-холинорецепторов membranes effector cells localized in the tip постганглионарных холинергических (парасимпатических) fiber, which prevents interaction with mediator acetylcholine : relaxes smooth posing declines секреция growing momentum increases curves. Противопаркинсоничес кая extends braking central м-холинергических structures and putting enabling холинергического influence базальные ганглии. Most distressing холинореактивные central system and to a lesser extent, affects the peripheral холинорецепторы. He has also ганглиоблокирующими and inflammatory properties. Acting on the central холинергические system reduces emission violations related to the defeat экстрапирамидной system.

Indications

Parkinson's disease, паркинсонизм, экстрапирамидные violation (спастический paralysis rigidity, гиперкинез, Литтля disease), causes the smooth muscles of internal organs, спастические constipation, saying disease stomach and duodenal ulcers, bronchial asthma, aetiology caused by the increasing strength wandering nerve, the threat of premature births, intoxication and organophosphorus compounds.

Restrictions on the use of

Diseases of the liver, kidneys, heart, hypertension, arteriosclerosis expressed.

Contraindications

Glaucoma, фибрилляция предсердий, мерцательная тахиаритмия whose urination.

Side-Effects

Гипосаливация, neuralgia, constipation, paralysis occlusion intestines, urine retention, the pupil, paralysis аккомодации, tachycardia, headache, dizziness, weakness, delirium, hallucinations, allergic reactions.

Patient interaction

Do парасимпатолитически е the impact of tricyclic antidepressants, violates induction леводопы, is the antagonism �ета-адреноблокаторам и.

Overdosing

Symptoms : violations of the central nervous system (causing hallucinations), dry mucous membranes and skin, increased inhibition, urine retention, tachycardia, the внутриглазного pressure, the increase in body temperature.

Dosing and Administration

Inside, the food. Adults in dose 10-12,5 mg twice a day. With good portable single dose can be increased to 15 to 20 mg (obstetric practice appoint 20 mg twice a day). Higher doses for adults : single 30 mg daily, 100 mg. For children 1-5 mg 1-2 times a day.

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