Benactyzine

Chemical name

альфа-Гидрокси-альфа-��енилбензолуксусной acid 2 -(диэтиламино)этиловы�� broadcast

Gross

C20-H25-N-O3

Characteristics

Refers to tertiary aminam. The white crystalline powder, soluble in water, it is difficult to alcohol. Aqueous solutions with the extended storage at hydrolysis.

Of drugs

The drugs-holinoliticescoe, skin, anxiolytic, protivoparkinsonicescoe, mestnoanestezirutee, midriaticescoe. Is m-holinoliticom is obratimuu blockade central (mostly), and peripheral holinoretseptorov. Warn development wagusnykh effects through indirect m-holinoretseptora. Oppressing sudorozhnoe or toxic effect antiholinesteraznah and holinomimeticakih substances. And anksioliticski and sedative effect kashleva down reflex. It midriaz (the pupil is a 10-30 minutes and lasts for quite p), reduces the secretion glands reduces smooth muscle layer is insignificant aguirutee impact on the hronotroponuu heart. Provides mestnoanestezirutee effect. Effective in Parkinson's disease and other disorders extrapiramidale, incl. medicinal.

Indications

Disturbing, astenoneuroticalkie and depressive disorders fobia, premedikation and posleoperazionny period; Sexually violent spazmom smooth muscles of internal organs (hospital disease stomach and duodenal ulcers, holetsistit, spasticeski Colitis, etc.), parkinsonism (combined therapy), neirodermit, cough.

Restrictions on the use of

Children's age (safety and efficacy of the children are not identified), old age.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, zakratougolnaya glaucoma, prostate adenoma cancer, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : midriaz, euphoria Golovokrugenie.so part of the intestine : dryness in the mouth, swelling tongue and palate (to the inside), nausea, Zapor.prochie : tachycardia, the delay urination.

Patient interaction

Do the pills funds (including barbiturates), analgesics, Neuroleptics, enervating, mestnoanesteziruth funds. Ters of antiholinesteraznah and m-holinomimetikov, incl. m-holinomimeticalkie rezerpina effects.

Overdosing

Symptoms : dwigatelnoe and mental arousal, convulsions, Galloucination.lechenie : washing stomach, activated carbon, proximity holinomimetiki (aminostigmin, galantamin, fizostigmin), symptomatic therapy.

Precautions

It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside (after delivery) by 1-2 mg 1-4 times a day; Treated 4-6 weeks.

Literature

1. Akopian NS, Sarkisyan NV, Karapetyan MA The role of the central and peripheral holinergicakih structures in the regulation of the electrical activity of the brain and heart activity rabbits in a гипоксии//Авиакосмиче ская and environmental medicine .- 1999 .- T. 33-N 1 .- C. 28-31.2. Transfiguration I.S, Ahno NN Treatment of Parkinson's disease / / Consilium Medicum .- 2002 .- V. 4-N 2-C 85-86.

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