Cyclopentolate

Chemical name

2-(Диметиламино)этилов ый broadcast �льфа-(1-гидроксицикло��ентил)бензолуксусной �islota (as hydrochloride)

Gross

C17-H25-N-O3

Characteristics

Molecular weight 327.85. Solutions for use in ophthalmolog 1a502 y are zabuferenne boratom solutions ziklopentolata hydrochloride.

Of drugs

The drugs-holinoliticescoe, midriaticescoe. And m-holinoliticaskoy activity. Its circular muscle iris ciliarnuu muscle eye. Increase position (midriaticescoe effect), and paralysis is ccomodation (zikloplegia). Easily penetrates the tissues eye. The effect is rapidly developing with a maximum zikloplegia achieved within 25-75 minutes, midriaz during 30-60 min after a single instillation. Complete recovery ccomodation usually occurs within 6 to 24 hours, the value of missed, in some cases, particularly in sensitive patients can return to the starting within a few days. To a small extent, reduces the secretion of salivary glands.

Indications

Eye diagnosis (ofthalmoskopia, refraktometria etc.), to create midriaza in inflammatory diseases front of the eyes (episclerit, sclerit, keratit, iridotsyklit, uveit) and the preparation of pre from extraction of cataracts.

Restrictions on the use of

Age up to 3 months.

Pregnancy and lactation

Not recommended (can be removals system, the experience of clinical use is not sufficient).

Contraindications

Hypersensitivity, zakratougolnaya glaucoma, predisposition to violate outflow vnutriglazna liquid (or narrow angle closed eyes).

Side-Effects

From the nervous system and sensory organs : local Improvement vnutriglaznogo pressure fotofobia, the shading, burning, eye irritation, hyperemia, conjunctivitis, blefarokongunguit, keratit point, sinehii; Dizziness, psychotic reactions, the behaviour ataxy, unusual drowsiness, weakness, it besswaznaya, anxiety, hallucinations, hyperactivity, seizures, the temporal and spatial Orientation.prochie : skin rashes, pregnant abdomen in children, thirst or dry mouth, nausea, tachycardia, giperpireccia, vazodilatation, urine retention, reducing gastrointestinal peristalsis, reducing secreting glands (port, salivary, mucous membranes Lor-organov and bronchi).

Specific guidance

To reduce systemic absorption to cause nososleznuu point during, and within 2-3 minutes after it (especially in children). In infants with regard to the possible lactose food feeding is recommended that no earlier than 6700, after applying the product. If fotofobia to protect the eye from Uf-sveta must be worn sun glasses. If fotofobia and / or shading is not receive within 36 h after instillation should consult with Vrachom.patienta гиперчувствительност ью atropino to prevent cross allergy to ziklopentolatu.

Patient interaction

Effect ziklopentolata may reinforce alfa-adrainomimetiki (fenilafrin), relax - m-holinomimetiki (pilocarpine). Ziklopentolat reduces protivoglaucomny and mioticeski carbahola effects, and pilocarpina antiholinesteraznah funds.

Overdosing

Treatment : In severe cases, being (in / in slowly, possibly p / j) antidote - fizostigmina musk; Adults and adolescents, 2 mg, with the signs of intoxication 1-2 mg 20 minutes later; Children - 0.5 mg (with persistent toxic effects and the absence of holinergicakih may reinstate in five minutes to a maximum cumulative dose of 2 mg).

Precautions

Children under two years of age is not recommended in a concentration of more than 0.5%. To apply caution in the elderly and patients with the risk of vnutriglaznogo pressure at Down syndrome in children with spastic paralysis or brain damage, the svetlokojih goluboglazykh children (there is an increased sensitivity to action ziklopentolata). Less effective for persons with temno-pigmentnami radujkami (residual ccomodation can reach 2.0-4.0 D). Children with polustoiki or resistant acute ccomodation better used for zikloplegii course instillation Atropina.u patients older than 40 years of ziklopentolata require monitoring vnutriglaznogo pressure and (if necessary) the gonioskopia.

Dosing and Administration

Locally, in burying kongungualny bag. In inflammatory eye diseases, and 1 drop three times a day, in the most severe cases, every 3-4 hours To improve pupil-on 1-2 drops 1-3 times at intervals of 10-20 minutes.

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