Detruzitol

Roman name

Detrusitol

Pharmacokinetics

Quickly and completely absorbed from the digestive tract. Bioavailability 17%, C_max in whey achieved after 1-3 hours Volume of 113 litres. Biotransformiroetsa in the liver with the formation of the active 5-gidroximetilland metabolita (with T_1/2, 3-4 h). Equilibrium concentration in the blood is achieved within 2 days. Excreted in the urine (77%) and faeces (17%).

Indications

Hypertension bladder, manifested by frequent mandatory impulses and / or urination.

Pregnancy and lactation

Contraindicated.

Contraindications

Hypersensitivity, the delay urination, chronic zakratougolnaya glaucoma, male gravis, Ulcerative Colitis, megakolon.

Patient interaction

Effect increase holinolitiki reduce-agonists m-holinoretseptorov. Ters activity metoklopramida and cizaprida.

Precautions

Before treatment to remove organic causes frequent and mandatory sneeze. Be wary appoint obstruction in the urinary tract, obstructive liver syndrome (incl. stenoze privratnika), kidney disease, liver (dose should not exceed 1 mg twice per day), neuropathy, nevprawima slipped. During therapy should avoid working with the mechanisms and the road.

Dosing and Administration

Inside. Adults - 2 mg twice a day, in violation of the liver and / or kidney-to 1 mg twice a day. In the case of side-effects dose also reduced to 1 mg twice a day. Through six months should assess the need for further Lechenia.ne encouraged to nominate children, as their safety and efficacy of the drug has not yet been explored.

Storage conditions

List B. The temperature is not above 25 ° C

Shelf life

3 years

The registration

010897

The drug forms

White, round, dvoyakovpuklae pills Film-coated. The tablet in 1 mg arc pattern above and below the letters SO, and the tablet 2 mg arc pattern above and below the letters DT.

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