Hyoscine butylbromide

Chemical name

[7(S)-(1альфа,2бета,4бета,5 альфа,7бета)]-9-Бутил-7-(3 -гидрокси-1-оксо- 2 -фенилпропокси)-9-мети��-3-окса-9-азониатрицик��о[3.3.1.02,4]нонана bromide

Gross

1000 C21-H30-Br-N-O4

Characteristics

Polusinteticescoe derivative giosciamina - alkaloid contained in krasavke, belene, durmane, skopolia. The white crystalline powder, readily soluble in water, soluble in alcohol.

Of drugs

Drugs, the skin, protivorvotnoe, antidiareynoe, antiaritmicescoe. Yes m-holinergicakie blocks receptors. It atropinopodobne effects : increased inhibition, paralysis ccomodation, raising vnutriglaznogo pressure greater automaticity sinusnogo unit showing curves, the acceleration sinoatrialna and AV conduction, stimulates activity functional AV node, relaxes smooth muscle blood, jelche- and urinary tract, cancer, bronchus, irritative slows down and reduces the secretion exkrethornykh glands (salivary, mucous membranes, port); at the holinoliticescoe expressed in the development of sedation, reducing motor activity. Selectively operates on the smooth musculature tract, mostly stomach, especially antralnogo Division, duodenal ulcer, gall bladder; Skin effect on the thin and large bowel were in doses of 2-10 times терапевтические.Плох�� absorbed in the digestive tract. Linking blood plasma low. The greatest concentration accumulates in the intestine, gall bladder and streams, liver and kidneys.

Indications

Increasing ulcers stomach and duodenal ulcers, diskinesia intestine, biliary tract and causes psoriasis ways pilorospazm in newborns sinusova aetiology, bradiaritmia when AV blockade parkinsonism, dismenorea, rinorea; Causing vomiting, gipersalivacia, diarrhoea, constipation spasticskie, night enourez, premedikation before surgery and diagnostic procedures (to improve relaxation and reduce secreta) Maritime and air sickness.

Contraindications

Гиперчувствительност ь (including from other belladonna alkaloids), glaucoma, porphyria, megakolon, spasticeski paralysis (children), tahiaritmii, arter 952 ial hypertension, male, filter disease strictora urinary tract, stenoticeskie changes intestine, bleeding, brain damage (children), Down syndrome, severe colita, liver disease and kidney school thyroid, Siegrena syndrome, pregnancy.

Side-Effects

Brown mouth, nose, and throat, dry skin, reduce odor, the decline in milk from lactating women, constipation, nausea and vomiting, difficulty urinating, the violation and ccomodation view, the sensitivity of the eye to light tachycardia, headache, drowsiness, weakness, agitation euphoria, irritability, anxiety, insomnia, amnesia, skin allergies Red skin at the injection.

Patient interaction

Antatsida, laxatives containing kaolin or attapulgit, ketokonazol, metoclopramide-weakened antiholinergiceski effect holinolitiki and Tricyclic antidepressants (amitriptyline, amoksapin, clomipramine, imipramin, nortriptilin, protriptilin, trimipramine) - increase. Deprimatia increase means oppressed CNS.

Overdosing

There is increasing pupils to the lack of response to light unto mucous membranes, ohriplostew vote obstruction glotania, palpitations, gipertermiei, giperemiei skin, human consciousness, hallucination, convulsions followed CNS oppression, stop breathing, parezom bowel and bladder Puzyr.lechenie : +68 diurez, re-introduction fizostigmina (every 1/2-1 hour) or galantamina (every 1-2 hours) to remove pareza bowel tachycardia might be proserina, with a moderate opening and small fits-magnesium sulfate; in the most severe cases - oskibutirat sodium rooms, IVL.

Precautions

There is a need to take into account a wide range of individual susceptibility to giostino possibility triggering hallucinations in the admission conventional doses to individual patients. The risk of side effects increases in old age. The admission of alcohol at the time of treatment. Avoid overheating in the intensive physical loads and on a hot day and hot baths and saunas. During therapy is not recommended driving cars and other activities requiring high speed response. To reduce dry mouth can be used chewing gum with sugar, broken pieces of ice saliva substitutes; Still more than 2 weeks dry mouth increases the risk of diseases of tooth enamel, gums, fungal infections. Cancel the drug should be gradually (with the quick lifting may cause nausea, goats, dizziness).

Dosing and Administration

Inside for 1/2-1 hours before the meal, between 10 and 20 mg 3-5 times a day; In / in, in / m or m / c, 20 mg 3-4 times a Sutki.detam over six years : the normal dose for adults. Children under 6 years : inside, 10 mg 3-5 times a day; In / in, in / m or m / to 3-6 years 10 mg three times a day; To 3 years 5 mg three times a day; Candle-rektalno 1 svece (10 mg) three times a day.

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