Ipratropium bromide

Chemical name

(эндо,син)-({+})-3-(3-Гидро��си-1-оксо-2-фенилпропо��си)-8-метил-8-(1-метилэт��л)-8-азониабицикло[3.2.1] -октана bromide

Gross

C20-H30-Br-N-O3

Of drugs

The drugs-bronhodilatirtee, skin. Does m-holinoretseptora smooth muscles traheobronhialnogo tree. With structural similarities to the molecule acetylcholine is its competitive antagonist. As derivative Quaternary little nitrogen soluble in fats and poorly diffuses through biological membranes. There is a low bioavailability-for tachycardia (systemic effects) to be inhaling about 500 doses, but only 10% is small and bronhiol alveol, and the rest are kept in the throat or mouth and proglatavetsa. The blood barely absorbed and excreted in faeces. Vsosavshayasa part (a) is metabolized into eight inactive or poorly antiholinergicakih active metabolites (derived from the urine). Bronhodilatiruty effect develops in 5-10 minutes after inhalation and continued for 5-6 hours Increase mostly large and medium-sized bronchi reduces the secretion of bronchial mucus.

Indications

Obstruguy chronic bronchitis, bronchial asthma, giperprodukcia patients, bronhoobstrukcia against colds.

Restrictions on the use of

Zakratougolnaya glaucoma, violations urination as a result of hyper prostate cancer, pregnancy, breast-feeding.

Pregnancy and lactation

Maybe (with the utmost care in the first trimester), if the effect of therapy outweighs the potential risk to the fetus and the child.

Contraindications

Гиперчувствительност ь.

Side-Effects

From the respiratory system : cough, it is very rarely paradoxical бронхоспазм.Аллергич��ские reactions : skin rashes, Krapiwnica.prochie : dry mouth, headache, nausea, the ccomodation (by ingestion eyes). From the respiratory system : dry mouth.

Patient interaction

Do bronholiticeski effect beta-adrainomimetikov xantinovykh and derivatives.

Dosing and Administration

Inhalation-2 aerosol dose (40 µ g), 4 times a day (if necessary up to 12 inhalations). Mortar for inhalations : adults and children older than 14 years, 0.1-0.5 mg 3-4 times a day through nebulaizer; Children 6-14 years 0.1-0.25 mg 3-4 times a day through nebulaizer; children up to six years in the 0.1-0.25 mg 3-4 times a day (under the supervision of a doctor).

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