Oxybutynin

Chemical name

4-(Диэтиламино)-2-бутин��ловый broadcast �льфа-циклогексил-аль��а- �идроксибензолуксусн��й acid

Gross

C22-H31-N-O3

Characteristics

The white crystalline solid mass with the molecular weight 393.9. Rastvorima easily in water and acid is relatively small in scheloch.

Of drugs

Drugs, the skin, miotroponoe. M-holinoretseptora block. Alleviate pain and reduces tone smooth muscle : blood, jelche- and urinary tract, uterus, particularly well relaxes smooth muscles bladder. Patients who are neirogennam bladder increases its capacity, relaxes and reduces the frequency of detruzora hinders craving and reduces the number mocheispuskani (unintended and arbitrary). It moved to a long-term, from one month to two years.

Indications

Neirogenny bladder, idiopathic unstable bladder (with a rising mocheispuskani, urination, urges the urinary, dizuriei and other symptoms); Giperreflexia and detruzora dysfunction; Enourez night and neirogenne of the bladder in children older than 5 years.

Contraindications

Hypersensitivity, glaucoma (zakryto- and otkratougolnaya), obstructive alleged violations, paralytic ileus, the expansion obodocna cancer (including toxic, combined ulcerative colitis), heavy colita, infants (including myasthenia gravis), obstructive uropathy etiology, atony ulcers in the elderly and handicapped patients, acute bleeding instability in the cardiovascular system, pregnancy, breast-feeding (at the end of treatment), Children age (up to five years).

Side-Effects

Brown mouth, nausea, vomiting, constipation, bloating, lower motor stomach and bowel disorders urination (including urine retention), palpitations, tachycardia, vazodilatation, weakness, dizziness, drowsiness or insomnia, anxiety, hallucinations, a decline of slezna fluid midriaz, raising vnutriglaznogo pressure ccomodation paralysis, visual impairment (ambliopia), reduced sweating, impotence, the suppression of lactation, allergic reactions (skin).

Patient interaction

Alcohol and other sedatives increase dizziness and drowsiness.

Overdosing

Symptoms : initiation CNS (anxiety, tremor, irritability, convulsions, delirium, hallucinations), reddening of fever, nausea, vomiting, tachycardia, hypothetical or hypertension, respiratory distress, paralysis Koma.lechenie : the maintenance of breathing apparatus induction vomiting, stomach wash; Can be activated charcoal and laxatives funds; Reversion to the symptoms of intoxication antiholinergicescoy appoint fizostigmin; In giperpirexii-cold wraps, including with ice, alcohol obtirania.

Precautions

Be wary when using neuro dystonia, liver and kidney diseases, gipertireoze, ischemic heart disease, congestive heart failure, tachycardia, aritmiah, hypertension, thyroid prostate cancer (especially in the early stages), nonspecific yazvennom kolite, diafragmalna slipped (including related gastroezofagealnam refluksom), diarrhea accompanying incomplete intussusception obstruction (especially in patients with ileo- or kolostoma) in old age. During treatment is not recommended to drive and the other activities that require high concentration and by the risk of their lives (can develop dizziness and impaired vision). It should be borne in mind that the high temperature environment are a source of fever and heart weakness (decreased sweating), while okshibutinina.

Dosing and Administration

Inside, and food. Doses and a unique destination. Typically, 5 mg (1 tab). 2-3 times (no more than 4) per day for adults and 2 times (no more than 3) per day for children over the age of 5 years; Maximum dose, 20 and 15 mg respectively. Older children and possibly a primary dose of 2.5-3 mg twice a day with a gradual increase to normal. When Shields night is the last admission at night.

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