Pirenzepine

Chemical name

5,11-Дигидро-11-[(4-метил-1- пиперазинил)ацетил]-6H- �иридо[2,3-b][1,4]бензодиа��епин-6-он (as dihydrochloride)

Gross

C19-H21-N5-O2

Of drugs

The drugs-protivoyazvennoe, gastroproteguoe. Selectively blocking m_1-holinoretseptora at intramuralnah gangliev and turns stimulating effect wandering nerve to jeludocnuu secretion. Zitoproteguoe effect linked to the improvement of circulation in the stomach mucosa and repression intragastralnogo Proteoliza.v blood drawn 1 / 2 - 1 / 3 doses. C_max plasma created in 3-4 hours About 10% is associated with blood plasma proteins. The GEB and placenta fails. Metabolized to a small extent. Reducing the plasma by 50% through a 20-hour Vsosavshayasa part of the preparation is news and jelchew unchanged in Vide.izbiratelno oppressing basal and stimulirovannuyu secretion of hydrochloric acid and pepsinoguena, reduces the activity of the gastric juice. Impact gastrina release, in response to the food irritation increases resistance cells mucous membrane of stomach damage. In gipersecretii to combine with blokatorami H_2-retseptorov gistamina and antatidami. At the beginning of therapy that combined oral and injecting : one dose of introducing / m and the other taken inside. In severe forms ulcers stomach and duodenal ulcers, for the treatment and prevention of bleeding, and erozi izgyazwleni appointed / m or / 386/1989 After improving (2-3 days) are in the process of oral ingestion.

Indications

Acute and chronic stomach ulcer and duodenal ulcer, gastritis giperatidnyi, ulcerated stomach virus, including medication.

Restrictions on the use of

Is not recommended to use in the first trimester of pregnancy.

Side-Effects

Headache, dry mouth, the ccomodation, lock / diarea.

Specific guidance

Your solutions should be used for a period of not more than 12 hours

Precautions

When a fast subjective improvement should not terminate employment because of the possible degradation. To use caution in patients with glaucoma and overdetermination prostate gland. The on / in the introduction to monitor the status of the cardiovascular system.

Dosing and Administration

Inside, in / m, / 386/1989 Inside -- 50 mg morning and evening for 30 minutes before eating, squeezed small amounts of water. The course of treatment is at least 4 weeks (4-8 weeks) without Pererava.pri heavy forms ulcers stomach and duodenal ulcers are introducing / m and / in the 10 mg every 12 C.pri disease Zollinger-Ellison dose increases by half.

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