Platyphylline

Chemical name

3-Этилиден-6-гидрокси-5, 6-диметилпергидро-1,8-д��оксациклододека[2,3,4-gh ] pirrolizin-2 ,7-dion (in the form of gidrotartrata)

Gross

C18-H27-N-O5

Characteristics

D. krestovnika (rombolistny or broad). The white crystalline powder bitter taste, easily soluble in water (1:5 in the hot, 1:10 in the cold), poorly soluble in alcohol. pH 0.2% solution-3,6-4,0.

Of drugs

Drugs, the skin, sossoudorasshiratee, sedative. Does m-holinoretseptora and has a direct relaksirutee impact on the smooth muscle. Increase receptacles lowers tone smooth muscles ERCP pancreatitis and gall bladder, bronchus is Midriaz.bystro and adequately absorbed in the digestive tract. Easily passes through gistogematicalkie barriers, and the cell membrane sinapticalkie. When a large dose accumulates in the tissues of the central nervous system in significant concentrations. Excreted urinary and digestive systems. If a (dose, the interval between meals) is not koumouliruet.

Indications

Cramps smooth muscles in the gastrointestinal ulcers stomach and duodenal ulcer, gastric, liver and kidney коликах, bronchial asthma, hypertension, stenocardia, cramps cerebrovascular, pain syndrome in панкреатите, панкреатическая coma, дискинезия psoriasis ways рефлюкс-эзофагит, брадиаритмии, acetone poisoning, boric acid, strong acids, arsenic, резерпином, diarrhea (mandatory craving) in the ophthalmic practice for the pupil for diagnostic and therapeutic purposes.

Contraindications

Glaucoma and the paucity of liver and kidney, paralysis or occlusion atony disease, Ulcerative Colitis, male.

Side-Effects

Brown mouth, the pupil, the ccomodation, rapid heartbeat, lowering AD breath, atony intestines, urine retention, causing convulsions.

Patient interaction

Increases the correct effect of phenobarbital and etaminala sodium blocking effects proserina increases-appointed interior H_2-gistaminolitikov, digoxin and riboflavine (down irritative and improves skin). Adrenomimetiki (midriaz increase), and nitrates potenziruut vnutriglaznogo increasing pressure amizil, dimedrol, Tricyclic antidepressants, hinidina sulphate, novokainamid, dizopiramid, isoniazid, MAO inhibitors, midantan - antiholinergicescuu activity. Alleviate bradycardia, nausea and vomiting caused by morphine, bradycardia with verapamila admission.

Overdosing

Symptoms : dry mouth, ohriplosti vote glotania violation, the pupils to the lack of response to the light, tachycardia, hyperthermia, red skin, the institution CNS followed oppression, a violation of consciousness, hallucinations, sudorozhny syndrome, respiratory distress, bowel paresis, the acute delay Mochi.lechenie : diurez accelerated, the introduction of cholinesterase inhibitors (fizostigmina, galantamina or proserina) paresis reduced bowel and reduce tachycardia; with a moderate opening and LOEL fits recommended that the magnesium sulphate, in the most severe cases - okshibutirata sodium rooms, IVL.

Dosing and Administration

Inside, c / GMT In spazmah smooth muscle (mild pain syndrome), c / to 1-2 ml of 0.2% solution. The course of treatment is the inside to the food 0,003-0,005 grams (children 0,0002-0,003 g) 2-3 times a day for 15 to 20 days. Higher doses : single 0.01 g, 0.03 daily and

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