Azamethonium bromide

Chemical name

[(Метилимино)диэтилен] бис(этилдиметиламмон��я dibromide)

Gross

C13-H33-Br2-N3

Characteristics

Symmetry biscetverticnoe ammoniewoye connection. White or white with a slightly yellowish white crystalline powder. Very гигроскопичен. Easily soluble in water and alcohol.

Of drugs

The drugs-ganglioblokirtee. Does n-holinoretseptora sympathetic and parasimpaticakih gangliev (delayed transfer of the case to preganglionarnah postganglionarnae fibre vegetative nerves), karotidnykh clubockov and hromaffinna napochechnikov tissue. Interrupt the nerve impulses through the week ганглии and alters the bodies of иннервацию nerves. Decreases flow vazokonstrictornah counters for receptacles and the adrenergicakih substances adrenal weakens pressorne reflex reaction. It is the peripheral vessels, hypotension, tachycardia, мидриаз violates аккомодацию eye expands bronchi моторику reduces the stomach, the secretion of glands, muscle bladder.

Indications

Hypertonic kriz, black lungs and brain, managed gipotenzia (in anesthesiology), causes peripheral vessels, including эндартериит, eclampsia, a disease hospital of stomach and duodenal ulcers, causes smooth muscles in the bowel, gall bladder, bronchus, the urinary tract (kidney колика) каузалгия; in the practice of Urology in tsistoskopia men (to facilitate passage through tsistoskopa uretru).

Contraindications

Hypersensitivity Arterial гипотензия, throm, degenerative changes in the central nervous system, kidney and / or liver failure.

Side-Effects

From the nervous system and sensory organs : general weakness, dizziness, short-term memory, the аккомодации eye injection pressure склер, мидриаз.Со the circulatory system and blood (blood, гемостаз) : ортостатическая гипотензия, тахикардия.Со part of the intestine : dry mouth, atony кишечника.Со the urogenital system : atony bladder.

Patient interaction

Gipotenzivny effect may reduce Tricyclic antidepressants, reinforce - nedepoliarizute muscle.

Overdosing

Symptoms : excessive гипотензия, ортостатический collapse, the strengthening of other side effects, oppression дыхания.Лечение : making sick of the приподнятыми lower limb; Antiholinesteraznah a LAN, альфа-адреномиметико�� (when expressed hypotension), m-holinomimetikov, oxygen, IVL.

Precautions

In order to prevent the development of collapse ортостатического need to stay patient in a horizontal position for a period of 2-2.5 hours after application.

Dosing and Administration

In / in, in / M.v / in slowly under the supervision of AD and the general condition in gipertonicescom krize, oteke light or brain 0.2-0.5 ml of 5% solution divorced 20 izotoniceski ml solution of sodium chloride or 5% glucose solution, or / m 2 ml of 5% solution. To run hypotension in / with drip 0.8-1.2 ml of 5% solution (0,04-0,06 g), the operation, if necessary 2,4-3,6 ml of 5% solution (0.12-0.18 g). B / m spazmah pressure and other conditions neurgentnykh 1 ml of 5% solution, by 1.5-2 ml 2-3 times a day. The maximum dose in the / m introduction : off 0.15 grams (3 ml of 5% solution), daily 0.45 g (9 ml of 5% solution).

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