Camphonium

Chemical name

N-(гамма-Диметиламиноп ропил)камфидина diyodmetilat

Gross

C17-H36-I2-N2

Characteristics

Biscetverticnoe ammoniewoye connection. White with a slightly yellowish white crystalline powder with light camphor smell, soluble in water and very soluble in alcohol.

Of drugs

The drugs-ганглиоблокирующее. Does n-holinoretseptora vegetative gangliev (delayed transfer of the case to preganglionarnah postganglionarnae fibre vegetative nerves) brain substance napochechnikov and sinocarotidna zone. Decreases vazokonstrictornah flow rate to pressure and the adrenalin glands weakens pressorne reflex reaction tone peripheral vessels, lowers round and AD. The blockade parasimpaticescoy innervation by lower motor activity of the digestive tract, oppression secreting glands, reducing bronchial spasms and bladder, a violation ccomodation eye.

Indications

Essential hypertension II art. Managed gipotenzia, saying disease stomach obliteriruty endarteriit.

Contraindications

Hypersensitivity Arterial gipotenzia expressed arteriosclerosis, chronic malnutrition koronarnaya, organic heart failure, myocardial infarction, thrombosis, bleeding in the boy's brain, glaucoma.

Side-Effects

From the nervous system and sensory organs : dizziness, general weakness, the ccomodation eye Midriaz.so the circulatory system and blood (blood, gemostaz) : ortostatical gipotenzia, Tahikardia.so part of the intestine : dry mouth, atony bowel (with long-term use), constipation.

Patient interaction

Tricyclic antidepressants may umenishati gipotenzivny effect.

Overdosing

Symptoms : excessive gipotenzia, ortostaticeski collapse, the strengthening of other side effects, oppression Dahania.lechenie : making sick of the pripodnatami lower limb; Antiholinesteraznah a LAN, альфа-адреномиметико�� (when expressed hypotension), m-holinomimetikov, oxygen, IVL.

Precautions

In order to prevent the development of ortostaticski collapse of the patient must be in a horizontal position for a period of 2-2.5 hours after application.

Dosing and Administration

In / in controlled hypotension on 0.25; 0.5; 1 ml of 1% solution in the 1-1.5 min. With long-standing operations may reinstate a 1-1.5 C.v / m subcutaneously to 0,005; 0.01; 0.05 g (0.5; 1; 5 ml of 1% solution); 1-3 times a Sutki.vnutri, regardless of meals for 0.01-0.1 g 1-2 times a day for two to three weeks; Possibly re courses.

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