Dimecolonium iodide

Chemical name

1,1,6-Триметил-2-[[2-(триме тиламмонио)этокси]кар бонил] piperidini diyodid

Gross

C14-H30-N2-O2-I2

Characteristics

Non biscetverticnoe ammoniewoye connection. White or nearly white with kremovatam white crystalline powder. Very easily soluble in water.

Of drugs

The drugs-ganglioblokirtee. Does n-holinoretseptora vegetative gangliev (oppressing transfer case with the preganglionarnah postganglionarnae fibre vegetative nerves), brain substance napochechnikov and sinocarotidna zone. It stops the pulse of holinergicakim nerves and alters the bodies of innervaciu nerves. Decreases vazokonstrictornah flow rate to pressure and the adrenalin glands weakens pressorne reflex reaction. Lowers tone arteries and veins, CSO, AD and the pressure in a small range of blood pressures in the miocard. Oppression parasimpaticescoy innervation by lower motor activity decreases, secreting glands, bronchial spasms and bladder, a violation ccomodation eye.

Indications

Diseases accompanied by spasms of smooth muscles, including saying disease stomach and duodenal ulcers, chronic gastritis, spasticeski Colitis, holetsistit, bronchial asthma (some forms), causes peripheral vessels, arterial hypertension; diengjefalny syndrome.

Contraindications

Hypersensitivity Arterial gipotenzia, acute myocardial infarction, thrombosis, feohromotsytoma, gipovolemia, shock, kidney and / or liver failure, degenerative changes in the central nervous system and it zakratougolnaya glaucoma.

Side-Effects

From the nervous system and sensory organs : weakness, dizziness, the ccomodation eye Midriaz.so the circulatory system and blood (blood, gemostaz) : ortostatical gipotenzia, Tahikardia.so part of the intestine : dry mouth, atony Kishechnika.so the urogenital system : atony bladder.

Patient interaction

Tricyclic antidepressants can reduce gipotenzivny effect.

Dosing and Administration

Inside before delivery, with ulcers stomach and duodenal ulcers, spazmah peripheral vessels : on 0,025-0,05 g 2-3 times a day for 3-4 weeks. In hypertension II art. : 0,025 g 1-2 times a day, rising to 0.05 g twice a day. The course of treatment 3-5 weeks.

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