Ganglefene

Chemical name

3-(Диэтиламино)-1,2-диме��илпропил-4-(2-метилпро��окси)бензоат (and as hydrochloride)

Gross

C20-H33-N-O3

Characteristics

Colorless crystalline powder odourless, easily soluble in water and alcohol, gigroskopichen.

Of drugs

The drugs-ganglioblokirtee. Does n-holinoretseptora sympathetic and parasimpaticakih gangliev (slowing of nerve stimulation to preganglionarnah postganglionarnae fibre vegetative nerves), karotidnykh clubockov and hromaffinna napochechnikov tissue. Increase peripheral vessels, reduces round, relaxes smooth muscles. Decreases motor activity stomach, the secretion of glands, muscle bronchi and bladder violates ccomodaqiu eye. Provides mestnoanestezirutee effect.

Indications

Diseases accompanied by spasms of smooth muscles, including abdominal (acute holetsistit, holangit, diskinesia psoriasis ways постхолецистэктомиче ский syndrome, etc.), the prevention of strokes; simpatoganglionit.

Contraindications

Hypersensitivity Arterial gipotenzia, degenerative changes in the central nervous system, kidney and / or liver failure.

Side-Effects

From the nervous system and sensory organs : dizziness, weakness, 877a deterioration in memory of ccomodation Glaza.so the circulatory system and blood (blood, gemostaz) : ortostatical gipotenzia, Tahikardia.so part of the intestine : dry mouth, tongue irritation followed anaesthetic (by ingestion language); Atony bowel Zapor.so the urogenital system : atony bladder, delay Mocheispuskania.prochie : allergic reactions; irritation and tissue necrosis (with a solution in a concentration of 1.5% and above).

Specific guidance

Solution product is not intended for on / in the (possibly fall AD).

Overdosing

Symptoms : excessive gipotenzia, ortostaticeski collapse, the strengthening of other side effects, oppression Dahania.lechenie : making sick of the pripodnatami lower limb; Antiholinesteraznah a LAN, альфа-адреномиметико�� (when expressed hypotension), m-holinomimetikov, oxygen, IVL.

Precautions

In order to prevent the development of collapse ortostaticski need to stay patient in a horizontal position for a period of 2-2.5 hours after application.

Dosing and Administration

Inside, before delivery, to 0.04 g 3-4 times a Sutki.p / to the in / m 0.015 g (1 ml of 1.5% solution) 3-4 times a day during the first two days and then on 0,03-0,045 g (2-3 ml) 3-4 times a day. In the 10th day of treatment per patient admission replace drugs into and within 4 days to go to the reception inside. The total duration of treatment-4-5 weeks. The maximum dose for adults : inwards single-0.075 g daily 0.3 g; C / to and / m time, 0.06 g (4 ml of 1.5% solution), daily - 0.18 g (12 mL 1.5% solution).

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