Hexamethonium benzosulfonate

Chemical name

1,6-бис-(N-триметиламмон ий)гексана dibenzolsulfonat

Gross

C24-H40-N2-O6-S2

Characteristics

Symmetry biscetverticnoe ammoniewoye connection. White or white with kremovatam melkochristalliceski white powder with a weak smell. Easily soluble in water, not in the alcohol.

Of drugs

The drugs-ganglioblokirtee. Does n-holinoretseptora vegetative gangliev (oppressing transfer case with the preganglionarnah postganglionarnae fibre vegetative nerves), karotidnykh clubockov and hromaffinna napochechnikov tissue. Decreases flow vazokonstrictornah impulses to receptacles, the adrenergicakih substances adrenal weakens pressorne reflex reaction. The tone down arteriol and veins, and outlines actions. Decreases motor activity of the stomach and intestine, and the secretion of endocrine glands, lowers tone bladder is the bronchi, the ccomodation eyes and numerical increase. Duration of 3-4 hrs

Indications

Essential hypertension II art. , Incl. mild PNDS krizov managed gipotenzia, causes peripheral arteries (endarteriit, peremejatayasa limp, etc.); saying disease stomach and duodenal ulcers, chronic gastritis, bronhospazm, diengjefalny syndrome.

Contraindications

Hypersensitivity Arterial gipotenzia, gipovolemia, shock, feohromotsytoma, acute myocardial infarction, thrombosis, degenerative changes in the central nervous system and it zakratougolnaya glaucoma, kidney and / or liver failure.

Side-Effects

From the nervous system and sensory organs : general weakness, dizziness, memory deterioration, respiratory depression, the ccomodation Glaza.so the circulatory system and blood (blood, gemostaz) : ortostatical gipotenzia, tachycardia, Cardialgia.so part of the intestine : dry mouth, atony bowel Zapor.so the urogenital system : atony bladder whose urination.

Specific guidance

When treating hypertension should be combined with saluretikami, gidralazinom or other antigipertenzivei drugs.

Patient interaction

Antiholinesteraznae drugs are antagonists. M-holinomimetiki remove the ccomodation eyes and eye syndrome and iron bladder alfa-adrainomimetiki - hypotension. Perhaps some enhanced effects antigistaminnah PP, narcotic analgesics, sedatives and tranquilizers PP, Neuroleptics and local anaesthetics, the sosudorasshirath and gipotenziveh drugs.

Overdosing

Symptoms : excessive gipotenzia, ortostaticeski collapse, the strengthening of other side effects, oppression Dahania.lechenie : making sick of the pripodnatami lower limb; Antiholinesteraznah a LAN, альфа-адреномиметико�� (when expressed hypotension), m-holinomimetikov, oxygen, IVL.

Precautions

It should be borne in mind the possibility of individual variability response to the product. With long-term use may reduce the effect (of tolerance). The start treatment with the lowest providing a dose effect, and then gradually increased. In order to prevent the development of collapse ortostaticski need to stay patient in a horizontal position for a period of 2-2.5 hours after application. It should be borne in mind the possibility of increasing the sensitivity of diabetes mellitus to the drug.

Dosing and Administration

Dropped (in / in, in / m, p / k) and the interior. For controlled hypotension in / in slow (within 2 min) 1.0-1.5 ml 2.5% Rastvora.podkozhno in / m for short PNDS krizov on 0.5-1 ml of 2.5% solution (0,0125-0,025 g). The possible introduction of products 3-4 times Sutki.vnutri for 1 hour before delivery, in the treatment of spasticity peripheral pressure, ulcers stomach and duodenal ulcers, 0.1 g 3-6 times a day. The inefficiency may increase doses up to 0.2 g per reception or a shift to p / c or / m introduction (0.25 ml of 2.5% solution four times daily before meals). Treatment generally conducted courses for 2; 4, or 6 weeks intermittently between 1-3 weeks. The maximum dose in the p / to the introduction : single-0.075 g daily 0.3 grams, and ingestion : single 0.3 g daily 0.9 g.

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