Pempidine

Chemical name

1,2,2,6,6-Пентаметилпипер идин (in the form of tartrate or толуолсульфоната)

Gross

C10-H21-N

Characteristics

White or white with кремоватым white crystalline powder. Easily soluble in water and alcohol.

Of drugs

The drugs-ганглиоблокирующее. Does n-holinoretseptora vegetative gangliev (slowing of nerve stimulation to preganglionarnah postganglionarnae Evoked parasimpaticalkie and fibre), karotidnykh clubockov (weakens pressorne reflex reaction), and tissue hromaffinna napochechnikov (reduces the adrenal glands). Increase peripheral vessels (reduces flow to вазоконстрикторных sympathetic impulses), improves blood circulation, reduces round, and arterial ORIONE pressure. Blocking the nerve impulses through the week hubs alter the bodies of innervaciu nerves, and it was tachycardia, a violation ccomodation eye midriaz, oppression secreting glands, the bronchi and lower vitality bladder. Spasmolytic effect is a consequence of the blockade парасимпатических ганглиев (down stimulating effect wandering nerve), and is lower reductions smooth muscles of internal organs (stomach, bladder, bronchi, etc.). Ganglioblokiruty and gipotenzivny effect continues 8 h Bolee.horosho drawn from the blood. Penetrates through ГЭБ and blocks central н-холинорецепторы. The potential use for the preparation of pre patients with pulmonary hypertension and chronic cor pulmonale.

Indications

Causes peripheral receptacles эндартериит, перемежающаяся limp; Arterial hypertension, including dysgravidism when pregnant, hypertonic kriz, saying disease stomach and duodenal ulcers, chronic gastritis, kolica (worms, jelcnaya, kidney), diengjefalny syndrome.

Contraindications

Hypersensitivity expressed arteriosclerosis, arterial гипотензия, гиповолемия, shock, acute myocardial infarction, organic heart failure, thrombosis, throm, low tone bowel and bladder different etiology, liver and / or kidney failure, degenerative changes in the central nervous system and it закрытоугольная glaucoma.

Side-Effects

From the nervous system and sensory organs : weakness, dizziness, loss of memory skoroprechodaschie personality disorders, tremor; Ccomodation violation eye midriaz, injection pressure Skler.so the circulatory system and blood (blood, gemostaz) : ortostatical gipotenzia, tachycardia, Cardialgia.so part of the intestine : dry mouth, atony ulcers, constipation, Meteorizm.so the urogenital system : atony bladder, urine retention.

Patient interaction

Do adrenomimetikov effects (increased sensitivity adrenoretseptorov result of the erosion of sports and norarenalina). Гипотензивный effect reduces Tricyclic antidepressants, reinforce Other гипотензивные means (possibly combined application).

Overdosing

Symptoms : increased by Effectov.lechenie : washing stomach, the holding of activities to maintain vital functions, symptomatic therapy, including introduction гипертензивных funds. To edema atony bladder and bowel atony possible introduction holinomimeticakih or antiholinesteraznah (proserin, etc.) funds.

Precautions

Treatment should be supervised by a doctor.

Dosing and Administration

Inside the 0.0025 g, in good endurance single dose increased to 0.005 g 2-5 times a day. Duration of treatment is 2-4-6 weeks intermittently between courses 2-3 weeks. The maximum single dose for adults is 0.01 grams daily $ 0.03 million and the hypertension during pregnancy single dose, 0.01 g.

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