Trakrium

Roman name

Tracrium

The composition and the form of

Solution for injection-1 mlatrakuriya bezilat-10 megawatts 182,000,000 2.5 and 5 ml, in a package 5 pcs.

Pharmacokinetics

Inaguiruetsa off by Hoffmann.

Clinical pharmacology

The effect is fast, with the 60-90, 15-30 continues with (depending on dose) and ends at the ferment and nefermentnam hydrolysis product (nonspecific esterase). Removing neiromysherngo unit is not dependent on pechenerngo and kidney metabolism, and excretion. Do not be affected by the n.vagus ganglia or not is not suitable for bradikardii related to the use of anesthetics or vagal stimulation (for transactions).

Indications

Relaxation skeletal muscles for endotrahealna intubations in general anesthesia, surgical operations IVL.

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus. Can be applied to kesarevom section.

Contraindications

Гиперчувствительност ь.

Side-Effects

Convulsions (in patients with predraspolagatei concomitant diseases); Red skin tranzitornaya gipotenzia, bronhospazm (related to the release of gistamina) anaphylacticskie reaction.

Patient interaction

Neuromuscular blockade increase alothane, izofluran, anfluran, aminoglikozida, polimiksin, spectinomycin, tetratziklin, linkomicin, clindamycin, propranolol, BAC, lidocaine, procainamide, quinidine, furosemide, mannit, tiazidnye dioretiki, acetazolamide, magnesium sulphate, ketamine, salt lithium trimetafan, gexametoni; Weaken - anticonwulsanta. Mask miasteniu gravis or cause miasteniceski syndrome (resulting in a high degree of sensitivity to drug), procainamide, quinidine, chloroquine, D-penitsillamin, trimetafan, chlorpromazine, steroids, phenytoin, lithium, propranolol, oxprenolol, antibiotics. Incompatible with depoliarizutmi miorelaxanthami (suxamethonium), as may sustainable neiromysherngo bloc to anticholinesterase means.

Precautions

In clinically meaningful cardiovascular disease and / or risk of hypotension (gipovolemia) should be slow (in the 60s). We confuse one sprite with tiopentalom or other alkaline products. The exercise in patients with гиперчувствительност ью gistaminu to.

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