Trepirium iodide

Chemical name

2-Карбокси-1,1-диметилп��рролидиния potassium broadcast with ( 2-гидроксиэтил)тримет��ламмония iodide

Gross

C12-H26-I2-N2-O2

Characteristics

Biscetverticnoe ammoniewoye connection. White or white with a slightly yellowish white crystalline powder dissolves easily in water (aqueous solutions fragile).

Of drugs

The drugs-ganglioblokirtee. Does n-holinoretseptora vegetative gangliev (delayed transfer of the case to preganglionarnah postganglionarnae fibre vegetative nerves) brain substance napochechnikov and sinocarotidna zone. Decreases vazokonstrictornah flow rate to pressure and the adrenalin glands weakens pressorne reflex reaction lowers AD. Gipotenzivny effect develops in 2-3 min after the introduction and lasts 10 to 15 minutes. AD restored to baseline values at 10-15 min after injection. The timing gipotenzivnogo effect adequate for use in anesthesiological practice to run hypotension. Owing to the embargo parasimpaticescoy innervation reduces motor activity of the stomach, the secretion of endocrine glands, muscle bronchus and urinary bladder, leading to the disruption of ccomodation eye.

Indications

Managed gipotenzia in anesthesiological practice kriz hypertonic; Brain swelling and light; Nephropathy and eclampsia (in obstetric practice).

Restrictions on the use of

Increased risk tromboobrazovania, old age.

Contraindications

Hypersensitivity Arterial gipotenzia, acute myocardial infarction, shock, thrombosis, degenerative changes in the central nervous system and it zakratougolnaya glaucoma, kidney and / or liver failure.

Side-Effects

From the nervous system and sensory organs : weakness, dizziness, the ccomodation eye midriaz, injection pressure Skler.so the circulatory system and blood (blood, gemostaz) : ortostatical gipotenzia, Tahikardia.so part of the intestine : dry mouth, atony bowel paralysis occlusion Kishechnika.so the urogenital system : atony bladder, anuria.

Specific guidance

Solution prepared immediately before use.

Patient interaction

Tricyclic antidepressants can reduce gipotenzivny effect.

Overdosing

Symptoms : excessive gipotenzia, ortostaticeski collapse, growing more side effects, oppression Dahania.lechenie : making sick of the pripodnatami lower limb; Antiholinesteraznah a LAN, альфа-адреномиметико�� (when expressed hypotension), m-holinomimetikov, oxygen, IVL.

Precautions

In order to prevent the development of collapse ortostaticski need to stay patient in a horizontal position for a period of 2-2.5 hours after application.

Dosing and Administration

B / drip in as a 0.1% solution (prepared by dissolving the powder in 0.9% solution of sodium chloride injection, or 5% glucose solution for injection), with a speed of 70 drops / min; after gipotenzivnogo effect of the speed reduced to 30-40 drops / Min.v / in slowly over 10 min (40-80 mg powder dissolved 3-5 ml of 0.9% solution of sodium chloride for injection).

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