Vecuronium bromide

Chemical name

1-[(2бета,3альфа,5альфа,16 бета,17бета)-3,17-бис-(Аце тилокси)-2-(1-пиперидин��л)андростан-16-ил]-1-мет илпиперидиния bromide

Gross

C34-H57-Br-N2-O4

Characteristics

The white crystalline powder, soluble in water and alcohol.

Of drugs

The drugs-miorelaksirutee (nedepoliarizutee). Does the azetilholinom n-holinoretseptora the skeletal muscles, preventing thus depolarization postsinapticescoy mionevralna membranes and is miorelaksaciu. And weak ganglioblokirutm act stimulates gistamina release from the depot. After the on / in a rapidly evolving miorelaxation, continued 20-35 min. The reintroduction of the blockade neiromyshecna transfer prolongiruetsa (effect until 60 minutes). Metabolised in the liver. Report the news in the form of metabolites.

Indications

Different types of interventions lumbar complex fractures, bone repozice otlomkov, with a mandatory transportation.

Restrictions on the use of

Expressions of the liver and kidneys, aged age.

Contraindications

Hypersensitivity, male, bronchial asthma, pregnancy.

Side-Effects

Hypotension, bronhospazm, allergic reactions.

Patient interaction

Effect increase barbiturates and other means deprimirutmi properties.

Dosing and Administration

In / in at the rate of 0.08-0.10 mg / kg (the dose is miorelaksaciu sufficient to ward trachea), hereinafter pH0.03 mg / kg or 1/2-1/4 of the initial dose.

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