Alcuronium chloride

Chemical name

4,4'-Дидеметил-4,4'-ди-2-пр опенилтоксиферин I dichloride

Gross

C44-H50-Cl2-N4-O2

Characteristics

Net derivative toksiferina, alkaloid curare.

Of drugs

The drugs-miorelaksirutee (nedepoliarizutee). Follow-up effect of competition with the azetilholinom n-holinoretseptora end plates skeletal muscles, which leads to blockade neiromyshecna transfer. Provides 1.5-2 times more powerful than d-tubokurarin. Unlike most other miorelaksantov this group has wagoliticakimi properties and is not conducive to the release of gistamina tissue depots. Specific antagonists - antiholinesteraznae funds. After the on / in the developing economies through 30, reaches a maximum 2-4 minutes and lasted 20-30 minutes.

Indications

Miorelaxation in diagnostic procedures and operational interventions, and the hypothesis gipertermiah, tetanus, IVL.

Restrictions on the use of

Later stages of pregnancy, and Metabolic elektrolitnye violations.

Contraindications

Hypersensitivity, amiotroficski lateral sclerosis, infants, polio, miopatia Dushenna, neirofibromatos, Conna syndrome, pregnancy (early).

Side-Effects

Hypotension, tachycardia, incredible, cardiac arrest, diarrhoea phenomenon bronhospazm, allergic reactions.

Patient interaction

Farmatsevticeski incompatible with tiopentalom sodium. Aminoglikozida, polimiksin, linkomicin, amphotericin B, tiazidnye dioretiki, furosemide, quinidine, etakrydinova acid 73.21 for narcosis, magnesium salt added miorelaksaciu, salt, potassium, calcium, sodium-reduced.

Dosing and Administration

B / 386/1989 For adults initial dose 0.25 mg / kg, again (being a 30 to 50 minutes and, if necessary, again in 15-25 min), 0.03 mg / Cg.dla children : initial dose to infants, 0.2 mg / kg, for low-0.1 mg / kg If anaesthesia is ziklopropanom, anfluranom, galotanom, izofluranom, metoksifluranom, dose should be reduced by 30-50%.

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