Pancuronium bromide

Chemical name

1,1 '- [(2beta .3 .5 alfa alfa ,16 beta, 17бета)-3,17-бис(Ацетилок си)андростан-2,16-диил]б ис[1-метилпиперидиния] dibromide

Gross

C35-H60-Br2-N2-O4

Characteristics

Crystalline powder almost white. Rat in the water and alcohol. Available in the form of liofilizirovannogo dry matter. Hydrogen-colourless, translucent liquid.

Of drugs

The drugs-miorelaksirutee. The competitive antagonist acetylcholine against n-holinoretseptoram skeletal muscles. And weak m-holinoblokirutmi properties to release gistamina of fabric depot. Connection with the plasma protein-low. A small portion is biotransformation in the liver with the formation of active metabolites, 90% excreted kidneys (80% in unmodified form), 10% presented with faeces. The action is in 2-3 min, a maximum-by 3-4,5 minutes, the duration of effect : 35-45 min. The full restoration neiromyshecna conductivity is about 60 minutes. The specific antagonists are antiholinesteraznae funds.

Indications

The miorelaxation in various surgical interventions using apparatus IVL.

Restrictions on the use of

In children under the age of one year (with a heightened sensitivity to the drug). There is no information on the safety of the pregnant women.

Contraindications

Hypersensitivity, bronchial carcinoma, respiratory depression, bronchial asthma, tachycardia, arterial hypertension, heart failure, dehydration, severe renal and hepatic failure, hypothetical or hyperthermia.

Side-Effects

Arterial hypertension or hypotension with the development of collapse, tachycardia, oedema, bronhospazm, hyperemia skin, allergic reactions : skin rashes, anaphylactic shock; Redness and soreness at the injection.

Patient interaction

Aminoglikozida, linkomicin, polimiksin increased and lengthened miorelaksirutee effect. It increases the risk of side effects of cardiac glycosides and lithium salts reduces the effectiveness бета-адреноблокаторо��.

Dosing and Administration

Adults and children over the age of 1 month, the initial dose at the rate of 0.04 mg / kg / 386/1989 Supported dose enter every 20-60 minutes at the rate of 0.01 mg / Kg.detam to 1 month in / in the dose introduced at the rate of 0.02 mg / kg

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