Suxamethonium chloride

Chemical name

2,2'-[(1,4-Диоксо-1,4-бутанд иил)бис(окси)]бис[N,N,N-т��иметилэтанаминия dichloride

Gross

C14-H30-Cl2-N2-O4

Characteristics

White melkochristalliceski powder. Easily soluble in water, very little in alcohol.

Of drugs

The drugs-miorelaksirutee. Depoliarizuet postsinapticescuu mionevralnuu spring. Resistant to the effects of synaptic inhibition, it is a matter of long-depoliarizatia muscle fibres and blockade neiromyshecna transmission being prolongiruetsa antiholinesteraznami means. In reconsidering or deferred the move in nepoliarizazionny block to the development of long-term respiratory depression and patients. Is gistamina released from the depot. The effect is a 0.5-1 min (in /) or 3 min (in / m). The impact for the on / in a 10-min (maximum after 1-2 min) in the m-a 10-30 min. Destroyed psevdoholinesterzoy blood plasma. Excreted kidneys (10% in an unmodified form).

Indications

Relaxation of the muscles of interventions : vpravljenie fractures, bone repozice otlomkov; Elektroimpoulsnaya therapy.

Contraindications

Hypersensitivity, bronchial asthma, male, pregnancy.

Side-Effects

Severe glaucoma, muscle pain in the aftercare period adults, aetiology, gipersalivacia, bronhospazm and hypotension, rabdomioliz development mioglobinemii and mioglobinurii, fever, allergic reactions.

Patient interaction

Potenziruet respiratory supresshiyu, wagusnye effects release gistamina caused by drug analgetikami, cardiotonicescuu activity cardiac glycosides reduces the effectiveness antimiasteniceskih funds. Antiholinesteraznae means salt magnesium and lithium, procainamide, quinidine, antidepoliarizute muscle prolong effect.

Dosing and Administration

For adult dose is as follows : / in the 0,3-1,1 mg / kg for the short-term and 0,6-1,1 mg / kg for long surgeries; In / m 3 and 4 mg / kg, but not more than 150 mg. In elektroimpoulsnoy therapy in / of 10-30 mg, in / m to 2.5 mg / kg, but not more than 150 mg. For children : / m to 2.5 mg / kg, but not more than 150 mg, in / 1-2 mg / kg Avoid re-introduction product!

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