Tolperisone

Chemical name

2-Метил-1-(4-метилфенил)- 3-(1-пиперидинил)-1-проп��нон (as hydrochloride)

Gross

C16-H23-N-O

Of drugs

The drugs-miorelaksirutee, sossoudorasshiratee. Does central n-holinoretseptora (incl. kaudalinah divisions retikuliarna formation), polisinapticalkie spinale though. The ingestion absorbed in a thin leg. C_max plasma determined by 0.5-1 hours Pronounced effect "of a" through the liver, resulting in low bioavailability (approximately 18%). Metabolised in the liver. T_1/2 the ingestion of 1.5 h, and on / in a 2.5 hours Significantly weakens muscle Spasticity.

Indications

Conditions associated гипертонусом skeletal muscles in the face of the organic neurological damage (damage to the pyramid, multiple sclerosis, миелопатия, encephalomyelitis, muscle spasm, muscle гипертонус, muscle contracture, спинальный automaticity), экстрапирамидные disorders (постэнцефалический and атеросклеротический паркинсонизм), epilepsy, vascular encephalopathy genesis, облитерирующие vascular disease (облитерирующий proper receptacles limbs, облитерирующий эндартериит, склеродермия system, облитерирующий тромбангиит, angiopatia diabetic, Reynaud syndrome), including : in the face of innervation receptacles posttromboticeskie human blood and lymphatic; in pediatrics is a disease Littl (child spasticeski paralysis).

Restrictions on the use of

Pregnancy, breast-feeding a young child (up to 3 years).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь (incl. to lidokaino), male heavy current.

Side-Effects

Neuralgia (nausea, vomiting, discomfort in the abdomen), drowsiness, reduced muscular strength arterial gipotenzia, allergic reactions (anaphylactic shock, bronhospazm, urticaria, erythema, skin itch).

Patient interaction

The effect of increasing funds for narcosis and peripheral muscle, psychotropic substances, klofelin.

Overdosing

Symptoms : respiratory depression (through pareza diaphragm and direct vent systems center) and heart activity, blood Gipotenzia.lechenie : symptomatic.

Dosing and Administration

Adults, inside-50 mg three times a day. B / m-1 ml (100 mg) twice a day. In / in-1 ml / day (100 mg) once. Children aged between 3 months to 6 years, inside-5 mg / kg / day for 3 admission. Children 7-14 years, the interior of 2-4 mg / kg / day in 3 admission.

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