Tubocurarine chloride

Chemical name

7',12'-Дигидрокси-6,6'-дим��токси-2,2,2'-триметилту��окурарания chloride hydrochloride

Gross

C37-H41-Cl-N2-O6.HCl

Characteristics

Crystalline powder. Nerastvorim in water.

Of drugs

The drugs-miorelaksirutee. The blockade n-holinoretseptorov skeletal muscles. After a single on / in the off occurs in two or three phases. T_1/2 men in the first phase is less than 5 minutes, the second from 7 to 40 minutes, in the third-more than 2 hours Place in an unmodified form with urine (mostly) and jelchew. If any of the kidney neiromyshecna blockade may lengthen. In re koumouliruet introductions. Gizzard paralysis consistently addresses the following muscle groups : rising forever, grinding, muscle limbs, abdominal, larynx, Intercostals muscles and diaphragm. Effects begin almost immediately after the / in the introduction, reaches an average of 5 minutes and lasts for 90 minutes. Neiromyshecnaya blockade is not predicated fastikulyatsiami muscles.

Indications

The miorelaxation during IVL, pharmacologically or electrically induced muscle cramp, diagnostics gravis.

Restrictions on the use of

Infants, severe kidney failure.

Contraindications

Гиперчувствительност ь.

Side-Effects

Rash, swelling and hypotension, collapse, tachycardia, bronhospazm. Violations of the heart rhythm, it stops, aetiology, gipersalivacia, allergic reaction (gistamina liberation).

Specific guidance

Use can only doctor who has experience with miorelaksantov, and the preparedness for tracheal intubations, oksighenoterapii.

Patient interaction

Effect weaken acetylcholine, antiholinesteraznae drugs, potassium, cold (hypothermia), added 73.21, anaesthetics, quinine, salt, calcium and magnesium, trimetafan, benzodiazepines, high doses beta-adrenoblokatorov, gipokaliemia, some antibiotics (neomycin, streptomycin, kanamycin), etc. muscle.

Overdosing

Many miorelaksaciei long. Treatment-hand or hardware IVL, the maintenance of the respiratory passage ways, the introduction of the antagonists (neostigmine, pyridostigmine).

Dosing and Administration

B / b - 0.25 mg / kg (complete muscle relaxation and patients still 20-25 minutes), you can enter it again, but each subsequent dose should be 1.5-2 times lower than the previous one.

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