Trihexyphenidyl

Chemical name

альфа-Циклогексил-аль фа-фенил-1-пиперидинпр опанол (as hydrochloride)

Gross

C20-H31-N-O

Characteristics

White melkochristalliceski powder. It is soluble in water, slowly soluble in alcohol.

Of drugs

The drugs - противопаркинсоничес кое. Does central m-holinoretseptora. Decreases tremor, to a lesser extent, affects the rigidity and bradikineziu. In connection with the flaccid m-holinoliticski action reduces sluno- and to a lesser extent, sweating.

Indications

Parkinsonism (idiopathic, ateroskleroticeski, postancefalitny, medicine), a disease Littl, spasticskie obesity related to defeat ekstrapiramidna pyramid and (more rarely) system.

Restrictions on the use of

Predserdy village, obstructive disease syndrome, urological diseases of the heart, kidneys, liver, blood pressure, pregnancy.

Contraindications

Zakratougolnaya form of glaucoma, prostate adenoma cancer stage III-IV.

Side-Effects

Brown mouth, paresis ccomodation, tachycardia, constipation, the urination, eight parotitis, xerostomii, headache, irritability, and the ability to focus, drug dependency, skin rashes.

Specific guidance

In patients over 60 years of age may be higher sensitivity, it is necessary to control the inner pressure. Pronounced side-effects during treatment reduced.

Patient interaction

When coupled with a blokatorami gistaminovykh receptors derivative fenotiazina, tricyclic antidepressants increased severity holinoliticakih peripheral effects. Levodopa increases противопаркинсоничес кую activity (possibly lower dose), rezerpin-less.

Overdosing

Many disabilities CNS-agitation delirium, hallucinations.

Dosing and Administration

Inside, the initial dose-0.5-1 mg / day, if necessary dose increased to 10 mg for 1-3 reception.

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