Acetylcholine chloride

Chemical name

2-(Ацетилокси)-N,N,N-трим��тилэтанаминия chloride

Gross

C7-H16-Cl-N-O2

Characteristics

Clear crystals or white crystalline mass. Easily soluble in water and alcohol.

Of drugs

The drugs-holinomimeticescoe. Implements of nerve impulses in the central nervous system, vegetative gangliah, okonchaniah parasimpaticakih and motor nerves, initiates membrane postsinapticalkie port glands. Interfaces with voice and n-holinoretseptorami is depoliarizatia membrane permeability increases for sodium ions, levelling potential voltage. Enlisting m-holinoretseptorov increases the "secondary mediators (Zamf and Atmf). Local sinapticeski capacity generates potential actions neirone next stages or more functional activity of the cell (muscle, cancer, etc.). The systemic effects predominate m-holinomimeticalkie effects : aetiology, the expansion of the blood vessels, reducing the AD, the famous and sokratimosti smooth muscle bronchus, stomach, uterus, pancreas and bladder, increasing digestive glands, bronchitis, port and sleznah glands, reduced inhibition (cramps), ccomodation patients. Impact inner pressure (when narrowing and missed uploshchenia iris growing schlemmov channel and space raduzhno-rogovicnogo angle improving outflow vnutriglazna liquid). Stimulating effect on the horse n-holinoretseptora gangliev (GSR and parasimpaticakih) is significant only when blockade м-холинорецепторов.Пр и ingestion ineffective because hydrolyses easily; in injecting provides rapid, but short-lived. After application in kongungualny bag skin to the blood to rezorbtivoe effect. Poor permeates through GEB.

Indications

Of the front chamber eye (removal of cataracts, keratoplastika, iridoektomia) for the mioza within a few seconds after release aphykia, causes retinal arteries, rarely endarteriit, peremejatayasa limp, nutritional disorder in kultah, atony bowel and bladder X ahalazii oesophagus.

Contraindications

Bronchial asthma, heart, stenocardia, ulcers, epilepsy, pregnancy.

Side-Effects

The systems use or removal system : narrowing of coronary vessels, aetiology and hypotension, reddening of difficulty in breathing, increased Potootdelenie.pri application in the eye : swelling, clouded cornea.

Patient interaction

Is antagonism with adrenomimetikami to influence the value missed. Beta-adrenoblokatora, antiholinesteraznae preparations adrenomimetiki increase protivoglaucomny effect. Tricyclic antidepressants, m-holinoblokatora, fenotiazin, hlorprotiksen, clozapin lower parasympathetic activity. Halothane increased by manifestations. When combined with hinidine possible ventricular fibrillation.

Overdosing

Symptoms : aetiology, the rhythm of the heart, lowering AD profuzny sweat, cramps, enhancing peristalsis of the bowel, Bronhospazm.lechenie : an on / in, c / a or / m introduction 0.5-1 ml of 0.1% solution of atropine (if necessary re), and rescue and bronhospazme collapse AD-0.1-1 ml of 0.1% solution via c / GMT

Precautions

Solution prepared immediately before use, as acetylcholine in the solution quickly Razlagaetsa.pri injections make sure that the needle is not named in suicide : in / with the introduction is not allowed (perhaps the result of the sharp decline in AD and cardiac arrest). Prolonged application (for a few years) in kongungualny bag could lead to a permanent miozu and education Petehi.dl rear extension mioza possible provisional instillace pilocarpina. In operation about cataracts apply only after a aphykia.

Dosing and Administration

Locally : causing evenly on the surface of the iris towards the corner missed 0.5-2 Ml.parenteralno : on 0.05-0.1 g s / to or / m 1-3 times a day. Higher doses s / to and / m : single 0.1 g daily 0.3 g.

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