Ambenonium chloride

Chemical name

N,N'-[(1,2-Диоксо-1,2-этанди ил)бис(имино-2,1-этанди��л]бис[2-хлор-N,N-д �этилбензолметанамин��я] dichloride

Gross

C28-H42-Cl4-N4-O2

Characteristics

White melkochristalliceski powder. Gigroskopichen. Easily soluble in water (up to 20%), soluble in alcohol.

Of drugs

The drugs-antiholinesteraznoe. Associated with the anionic center enzyme and its reversible blocks. Prevents hydrolysis acetylcholine contributes to the accumulation of okonchaniah holinergicakih nerves, and enhances prolong proceedings and muskarin- никотинчувствительны х receptors. M-holinomimeticescoe effect is to increase strength and contractile activity of smooth muscle bronchus, stomach, uterus, pancreas and bladder, improve digestive glands, bronchitis, and the port sleznah glands, decreased inhibition (cramps), spazme ccomodation, reducing vnutriglaznogo pressure bradikardii, expanding blood vessels, reducing AD. Accumulation of acetylcholine in n-holinoretseptorov facilitates the process of synaptic transmission and improves neuromuscular conductivity, but the highest concentration is the opposite effect. In high doses, can cause tachycardia (through stimulation n-holinoretseptorov active membranes sympathetic gangliev, think napochechnikov layer and the oblong brain). Increases endurance and motor activity increases movements and muscle Silu.effectiven with ingestion. Poor passes through gistogematicalkie Barriera.nacinet work through 0.5-1.5 h, the effect continues until 10 hours or more.

Indications

Male, propulsion of the meningitis, encephalitis, polio, amiotroficski lateral sclerosis, obesity peripheral facial nerve, the effects of central nervous system injuries.

Contraindications

Epilepsy, giperkineza, bronchial asthma, stenocardia expressed arteriosclerosis, mechanical intestinal occlusion, human urine, aetiology, pregnancy.

Side-Effects

Gipersalivacia, enhancing peristalsis, nausea, diarrhea, frequent urination, sweating, cramps.

Patient interaction

Antipruritic drugs with deprimating activity novocaine, novokainamid, hinidina sulphate, ganglioblokatora, Tricyclic antidepressants reduce the effectiveness. M-holinoblokatora weaken, strengthen m-holinomimetiki мускариномиметически е effects. Beta-adrenoblokatora deepen cardiodepressiu (aetiology). Decreases miorelaksaciu caused kurarepodobnami antidepoliarizutmi drugs and антибиотиками-аминог��икозидами. Papaverina hydrochloride weakens tonizatiou smooth muscles.

Overdosing

Symptoms : enhanced peristaltika, spasticskie pain in the abdomen, vomiting, diarrhoea, gipersalivacia, cold sweat, frequent urination, impaired vision and glotania, coma, muscle jerkiness language and skeletal muscles, paralysis of skeletal muscles, the AD aetiology, the subjective sense of "internal drojania" Trevogi.lechenie sense : in / with the introduction of 0.5-1 mg atropine, if necessary, IVL, traheotomia, oxygen; all activities conducted against the backdrop of the reception.

Precautions

When combined with a more antimiastenicescimi means caution (possible overdose).

Dosing and Administration

Inside, after Eda.miastenia : 5 mg, the dose gradually increased (1 mg) to obtain clinical effect; Normal single dose for adults-10 mg, if necessary, 20 mg, in the lungs cases 1-2, in the heavy-five to six times a day, with the space between meals at least 4 hours (to exclude cumulative), children reduces the dose, depending on the Vozrasta.lechenie polio : children 1-2 years, 1-2 mg, 2-5 years, 2-3 mg, 6-10 years, 3-5 mg, 11-14 years 5-7 mg, over 14 years, 10 mg; once a day, every day or every two days; treatment is 15-20 receptions; refresher courses through 2-3 Mes.dwigationa violations after meningitis, encephalitis and central nervous system injuries, paralyses facial nerve : adult-to 5 mg 2-3 times a day, changing the dose, depending on the acceptability and effect; children up to 10 years - to 1 mg per year of life per day (2-3 receiving). The course of treatment is two to three weeks. Higher doses for adults inside : single 25 mg, daily, 75 mg.

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