Amiridin

Chemical name

9-Амино-2,3,5,6,7,8-гексаги��ро-9Н-циклопента[b]хин��лина Hydrochloride Monohydrate

Gross

C12-H19-Cl-N2-O

Characteristics

White melkochristalliceski powder. Easily soluble in water and ethanol.

Of drugs

The drugs-antiholinesteraznoe. Reversible ingibiruet holinesterzu hinders enzimaticescomu hydrolysis acetylcholine, stabilizes mediator in the synaptic junctions and reinforces holinergicescuu transfer impulses. Blocking potassium channels membranes and promotes their depolarization. Improves the initiation of the peripheral nervous system, increases the acetylcholine and other mediators (adrenaline, serotonin, histamine, oxytocin) is not smooth muscles, restores neuromuscular transfer to skeletal muscles. The radio and n-holinomimeticalkie effects enhances tone and airway smooth muscles of internal organs, including Stomach and bronchus (up to bronchospasm), urejaet numerical increases secretion of salivary glands (gipersalivacia) Oxytocics Oxytocics activity, muscle skeletal muscles. It stimulates the central holinergicescuu transfer, has a stimulative effect on the central nervous system in combination with some forms of sedative effect, improves cognitive functions, including learn Pamati.bystro drawn from the blood, mostly gastrointestinal bleeding (less from thin face and bowel, and 3% of the stomach). Once inside the dose of 10 mg / kg S_max blood achieved through 1hr Well-distributed, metabolised in the liver, excreted by the kidneys kanalzeva secreta (2 / 3) or clubockova filter (1 / 3). T_1/2 : 40 minutes, not koumouliruet.

Indications

Diseases of the nervous system : neitropatia, rapid, polinevrit, mielopoliradikulonevrit, bulbarnae obesity and pareza with organic CNS lesions accompanied by motor disabilities; Male and miasteniceski syndrome; Multiple sclerosis and other demielinizirute diseases of the nervous system; Dysfunctions of central nervous system (low memory, concentration, motivation, initiative, disorientation, emotional lability, etc.) senilna with dementia, Alzheimer's disease, encephalopathy, violation of cerebral circulation, head injuries, cerebral dysfunction with learning difficulties in children; atony bowel weakness generic activities; antiholinergicakimi intoxication means.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, ekstrapiramidnye violations associated giperkinezami, epilepsy, bronchial asthma, stenocardia, aetiology, the propensity to westibulyarian disorders, pregnancy, breast-feeding.

Side-Effects

Allergic reactions : skin itch, Sapi.prochie : m-holinomimeticalkie effects-bronhospazm, aetiology, gipersalivacia, diarrhoea; Anorexia, nausea and vomiting, jaundice, dizziness, ataxy.

Patient interaction

Ters dampening effect on neuromuscular transmission and the initiation of the peripheral nervous system, local anesthetics, antibiotics, potassium chloride. Atropine and metoqinia iodide kupeeroout symptoms of overdose and individual гиперчувствительност и.

Precautions

If you have side effects should be reduced dose (the treatment is not usually required).

Dosing and Administration

Inside, c / a, in / m. Losses peripheral nervous system - to 20 mg three times a day; Male, miasteniceski syndrome, demielinizirute defeat of the nervous system, for 20 to 40 mg three times a day with a maximum daily dose of 180-mg; Mild miasteniceski kriza of 5-15 mg 1-2 times a day p / c or / m; Alzheimer's, senillnaya dementia in individual dose, but not more than 200 mg / day (high dose recommended 4-5 times a day at intervals of 2-3 h); duration of 1 month to 1 year; atony ulcers on 15-20 mg 2-3 times a day for 1-2 weeks; Stimulation generic activities, and 20 mg 1-3 times at intervals of 10 min.

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