Distigmine bromide

Chemical name

3,3'-[1,6-Гександиилбис[(м етилимино)карбонил]ок си]бис[1-метилпиридини я] dibromide

Gross

C22-H32-N4-O4-Br2

Characteristics

Powder white. Rat in the water.

Of drugs

The drugs - м-н-холиномиметическо е indirect. Ingibiruet (reversible) azetilholinesterzu and leads to the accumulation of acetylcholine in the synaptic junctions. Clinical effect develops over 1-1.5 h after administration inwards. It stimulates the secretion of exokrinnah glands, increases tone and irritative bowel and bladder. Increased muscle blood reaches the maximum 10 hours and lasts for 20 hours There cardiovascular : Provides moderately expressed sossoudorasshiratee and hronotroponoe negative effect. Increases tone skeletal muscles, especially when gravis (noticeable effect appears on the 1-2 day admission).

Indications

Paralytic ileus, postoperative bowel atony (prevention and treatment), chronic constipation, atony bladder and mochetocnikov, neirogenne urination disorder associated with a functional deficiency pouches bladder, male.

Contraindications

Гиперчувствительност ь (incl. to bromu) expressed wagotonia (aetiology, arterial gipotenzia, giperatidnye state increased slunootdelenie), bronchial asthma, refluksnaya disease hospital stomach disease, inflammatory bowel disease; infection, kidney and liver cramps, chronic heart failure, myocardial infarction, the peripheral blood circulation, thyrotoxicosis, and clauniceskie Hospital convulsions, parkinsonism, pregnancy, breast-feeding.

Side-Effects

Diarrhoeal phenomenon gipersalivacia, intestinal kolica, bronhoobstruguye violations sinusova aetiology, cramps, sweating, tremor, muscle cramp, difficulty glotania, menstrualnopodobne bleeding (with a functional amenoree).

Patient interaction

Antiholinergicakie and the holinoliticaskoy activity (psychotropic, antihistamines, aminoglikozida) drugs weaken effect.

Overdosing

Symptoms : gipersalivacia, nausea, vomiting, diarrhea, stomachache spasticski nature, muscle weakness, fastikulyatsii, sweating, bronhospazm expressed Bradikardia.lechenie : as a specific antidote is atropine.

Precautions

It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention. There should be strict adherence to a reception (no more than once a day), and in long-term care for a day of rest (possible accumulation).

Dosing and Administration

Inside, in / m. Inside for 30 minutes before breakfast, starting with the 5 mg / day, and then, depending on the effectiveness and acceptability, dose increased to 10 mg daily or reduced to 5 mg once every 2 or 3 days. In myasthenia use much greater doses. B / m - 0.5 mg, re-injection made no earlier than a day after the first injection.

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