Donepezil hydrochloride

Gross

C24-H29-N-O3.H-Cl

Characteristics

Represents piperidine derivative.

Of drugs

The drugs-antiholinesteraznoe. Ingibiruet holinesterzu and blocks acetylcholine disintegration conducting normal transfer to the central nervous system. Wrinkles progression of Alzheimer's disease, reduces the severity of cognitive symptoms (according to the test Folstein), in some cases, restores daily activity sick and facilitates caregivers. Corrects behavioral violations : apathy, hallucinations and neosmaslenne repetitive movement.

Indications

Alzheimer's Disease mild (symptomatic treatment of cognitive).

Contraindications

Hypersensitivity, the disruptions, saying disease stomach and duodenal ulcers, bronchial asthma, chronic obstructive lung diseases, pregnancy, child.

Side-Effects

Diarrhoeal events (nausea, vomiting, diarrhea), headache, dizziness, fatigue, insomnia, convulsions, fainting, aetiology, violations sinoatrialna and AV conduction, raising CPK.

Patient interaction

Effect reinforce others antiholinesteraznae means inhibitors zitohroma P450 (down biotransformatia) weakening - holinoblokatora, induktora monooksigenazna system (rifampicin, phenytoin, ethanol, etc.). If you are a means to narcosis, NPVS the likelihood of adverse events.

Precautions

Treatment is carried out under compulsory medical supervision. One of the conditions for effective therapy is the most appropriate care for patients. During the course should abandon admission alcohol.

Dosing and Administration

Inside, one at night (at night) in the dose of 10 mg for 6 weeks. Admission continue if no improvement (with the words relatives or those caring for the patient).

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